Mangiferin induces the expression of a thermogenic signature via AMPK signaling during brown-adipocyte differentiation
DC Field | Value | Language |
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dc.contributor.author | Rahman, Md Shamim | - |
dc.contributor.author | Kim, Yong-Sik | - |
dc.date.accessioned | 2021-08-11T08:34:25Z | - |
dc.date.available | 2021-08-11T08:34:25Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.issn | 1873-6351 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2693 | - |
dc.description.abstract | Mangiferin (MF) from Mangifera indica has been serendipitously found to ameliorate obesity and is used as an antioxidant, anti-inflammatory, antimicrobial, and anticancer agent. Nonetheless, the mechanism of MF-induced brown-adipose-tissue activation has not been studied. Therefore, we investigated the effect of MF on thermogenic features during brown-adipocyte differentiation. Treatment with MF improved the expression of a brown-fat signature and of mitochondrial-mass-related genes, thus resulting in UCP1 induction. MF also raised the expression of other thermogenic regulators, including peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC1 alpha), PR domain-containing protein 16 (PRDM16), and peroxisome proliferator-activated receptors alpha and gamma (PPAR-alpha and -gamma). MF promoted mitochondrial biogenesis, judging by increased expression of cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA), mitochondrial transcription factor A (TFAM), iodothyronine deiodinase 2 (DIO2), cytochrome c oxidase subunit 7A (COX7A), cyclooxygenase 2 (COX2), sirtuin 1 (SIRT1), and nuclear respiratory factor 1 (NRF1). MF treatment increased the mitochondrial DNA amount and improved mitochondrial respiratory function by increasing the oxygen consumption rate during brown-adipocyte differentiation. A gene knockdown assay involving small interfering RNA and competitive inhibition with dorsomorphin revealed that MF may promote thermogenesis in brown pre-adipocytes via activation of AMPK signaling. Collectively, our findings suggest that MF may be a novel pharmaceutical agent that can ameliorate obesity via activation of brown adipose tissue. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Mangiferin induces the expression of a thermogenic signature via AMPK signaling during brown-adipocyte differentiation | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.fct.2020.111415 | - |
dc.identifier.scopusid | 2-s2.0-85084758248 | - |
dc.identifier.wosid | 000541110800038 | - |
dc.identifier.bibliographicCitation | Food and Chemical Toxicology, v.141 | - |
dc.citation.title | Food and Chemical Toxicology | - |
dc.citation.volume | 141 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | FAT DEVELOPMENT | - |
dc.subject.keywordPlus | PPAR-ALPHA | - |
dc.subject.keywordPlus | AUTOPHAGY | - |
dc.subject.keywordPlus | PGC-1-ALPHA | - |
dc.subject.keywordPlus | MUSCLE | - |
dc.subject.keywordPlus | SIRT1 | - |
dc.subject.keywordPlus | WHITE | - |
dc.subject.keywordAuthor | Mangiferin | - |
dc.subject.keywordAuthor | brown preadipocyte | - |
dc.subject.keywordAuthor | Thermogenesis | - |
dc.subject.keywordAuthor | Mitochondrial biogenesis | - |
dc.subject.keywordAuthor | AMPK | - |
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