Autophagy Suppresses Toll-Like Receptor 3-Mediated Inflammatory Reaction in Human Epidermal Keratinocytes
DC Field | Value | Language |
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dc.contributor.author | Li, Xue Mei | - |
dc.contributor.author | Jung, Kyung Eun | - |
dc.contributor.author | Yim, Su Hyuk | - |
dc.contributor.author | Hong, Dong Kyun | - |
dc.contributor.author | Kim, Chang Deok | - |
dc.contributor.author | Hong, Jeong Yeon | - |
dc.contributor.author | Lee, Ho Jung | - |
dc.contributor.author | Lee, Sung Yul | - |
dc.contributor.author | Kim, Jung Eun | - |
dc.contributor.author | Park, Chang Wook | - |
dc.date.accessioned | 2021-08-11T08:36:06Z | - |
dc.date.available | 2021-08-11T08:36:06Z | - |
dc.date.issued | 2020-05-05 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.issn | 2314-6141 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2829 | - |
dc.description.abstract | Autophagy, one mechanism of programmed cell death, is fundamental to cellular homeostasis. Previous studies have identified autophagy as a novel mechanism by which cytokines control the immune response. However, its precise role in immune-related inflammatory skin diseases such as psoriasis remains unclear. Thus, this study explored the functional role of autophagy in psoriatic inflammation of epidermal keratinocytes. Strong light chain 3 immunoreactivity was observed in epidermal keratinocytes of both human psoriatic lesions and imiquimod-induced mice psoriatic model, and it was readily induced by polycytidylic acid (poly (I:C)), which stimulates Toll-like receptor 3 (TLR3), in human epidermal keratinocytes in vitro. Rapamycin-induced activation of autophagy significantly reduced poly (I:C)-induced inflammatory reaction, whereas, inhibition of autophagy by 3-methyladeine increased that. Our results indicate that the induction of autophagy may attenuate TLR3-mediated immune responses in human epidermal keratinocytes, thus providing novel insights into the mechanisms underlying the development of inflammatory skin diseases including psoriasis. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Hindawi Publishing Corporation | - |
dc.title | Autophagy Suppresses Toll-Like Receptor 3-Mediated Inflammatory Reaction in Human Epidermal Keratinocytes | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1155/2020/4584626 | - |
dc.identifier.scopusid | 2-s2.0-85085346021 | - |
dc.identifier.wosid | 000536802100007 | - |
dc.identifier.bibliographicCitation | BioMed Research International, v.2020 | - |
dc.citation.title | BioMed Research International | - |
dc.citation.volume | 2020 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | PSORIASIS | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | IL-1-BETA | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | toll like receptor | - |
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