Comparative study on biodegradation and biocompatibility of multichannel calcium phosphate based bone substitutes
DC Field | Value | Language |
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dc.contributor.author | Kang, Hoe-Jin | - |
dc.contributor.author | Makkar, Preeti | - |
dc.contributor.author | Padalhin, Andrew R. | - |
dc.contributor.author | Lee, Gun-Hee | - |
dc.contributor.author | Im, Soo-Bin | - |
dc.contributor.author | Lee, Byong-Taek | - |
dc.date.accessioned | 2021-08-11T08:36:18Z | - |
dc.date.available | 2021-08-11T08:36:18Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 0928-4931 | - |
dc.identifier.issn | 1873-0191 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2883 | - |
dc.description.abstract | The objective of this study was to fabricate multichannel biphasic calcium phosphate (BCP) and beta-tricalcium phosphate (TCP) bone substitutes and compare their long-term biodegradation and bone regeneration potentials. Multi-channel BCP and TCP scaffolds were fabricated by multi-pass extrusion process. Both scaffolds were cylindrical with a diameter of 1-mm, a length of 1-mm, and seven interconnected channels. Morphology, chemical composition, phase, porosity, compressive strength, ion release behavior, and in-vitro biocompatibility of both scaffolds were studied. In-vivo biodegradation and bone regeneration efficacies of BCP and TCP were also evaluated using a rabbit model for 1 week, 1 month, and 6 months. BCP exhibited superior compressive strength compared to TCP scaffold. TCP showed higher release of both calcium ions and phosphorous ions than BCP in SBF solution. Both scaffolds showed excellent in-vitro biocompatibility and upregulated the expression of osteogenic markers of MC3T3-E1 cells. In-vivo studies revealed that both cylindrical TCP and BCP scaffolds were osteoconductive and supported new bone formation. Micro-CT data showed that the bone-regeneration efficacy of TCP was higher at one month and at six months after implantation. Histological examination confirmed that TCP degraded faster and had better bone regeneration than BCP after 6 months. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Comparative study on biodegradation and biocompatibility of multichannel calcium phosphate based bone substitutes | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.msec.2020.110694 | - |
dc.identifier.scopusid | 2-s2.0-85078922124 | - |
dc.identifier.wosid | 000527395900069 | - |
dc.identifier.bibliographicCitation | Materials Science and Engineering: C, v.110 | - |
dc.citation.title | Materials Science and Engineering: C | - |
dc.citation.volume | 110 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | BETA-TRICALCIUM PHOSPHATE | - |
dc.subject.keywordPlus | HA/BETA-TCP | - |
dc.subject.keywordPlus | GRAFT SUBSTITUTES | - |
dc.subject.keywordPlus | SCAFFOLD | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | BIOCERAMICS | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | CERAMICS | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | POROSITY | - |
dc.subject.keywordAuthor | Multichannel | - |
dc.subject.keywordAuthor | BCP | - |
dc.subject.keywordAuthor | TCP | - |
dc.subject.keywordAuthor | Biodegradation | - |
dc.subject.keywordAuthor | Bone substitute | - |
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