Age-associated changes in chronic rhinosinusitis endotypes
DC Field | Value | Language |
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dc.contributor.author | Ryu, Gwanghui | - |
dc.contributor.author | Dhong, Hun-Jong | - |
dc.contributor.author | Park, Minsu | - |
dc.contributor.author | Hwang, Na Young | - |
dc.contributor.author | Kim, Dong-Kyu | - |
dc.contributor.author | Kim, Hyo Yeol | - |
dc.contributor.author | Chung, Seung-Kyu | - |
dc.contributor.author | Rhee, Chae-Seo | - |
dc.contributor.author | Cho, Seong-Ho | - |
dc.contributor.author | Hong, Sang Duk | - |
dc.contributor.author | Kim, Dae Woo | - |
dc.date.accessioned | 2021-08-11T08:36:20Z | - |
dc.date.available | 2021-08-11T08:36:20Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 0954-7894 | - |
dc.identifier.issn | 1365-2222 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/2894 | - |
dc.description.abstract | Background Immunologic function in innate and adaptive immunity changes with the ageing process. Thus, age-related cytokine profiles in chronic rhinosinusitis (CRS) need to be investigated for precision medicine. Objective The objective of this study was to characterize age-related changes in immunologic profiles according to CRS subtypes. Methods Subjects in control (n = 29), CRS without nasal polyps (CRSsNP, n = 86), and CRS with nasal polyps (eosinophilic NP: ENP, n = 81; non-eosinophilic NP: NENP, n = 113) were enrolled in this study. Twenty markers for type 1/2/3 inflammation and other inflammatory processes were measured in homogenates of sinonasal tissues and statistically analysed. Results In control tissues, type 2/3 and proinflammatory mediators showed an inverse correlation with age. CRSsNP and NENP showed an age-related increase in type 2 cytokines and a decline in type 3 cytokines. Interestingly, the age-related decrease in type 3 mediators was associated with those of CT scores in NENP. ENP showed an age-related increase in type 3 cytokines with type 2 mediators sustained at high levels. Smokers with ENP demonstrated age-associated increases in type 1/2/3 mediators as well as CT scores. These age-related patterns in each CRS were confirmed by statistically adjusting atopy status, smoking history, and disease duration. Conclusion Age-associated cytokine changes differed among CRS subtypes and control tissues. CRSsNP and NENP demonstrated a decline in type 3 mediators and increase in type 2 mediators, whereas type 3 mediators increased with age in ENP. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Age-associated changes in chronic rhinosinusitis endotypes | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/cea.13586 | - |
dc.identifier.scopusid | 2-s2.0-85080132991 | - |
dc.identifier.wosid | 000516847600001 | - |
dc.identifier.bibliographicCitation | Clinical and Experimental Allergy, v.50, no.5, pp 585 - 596 | - |
dc.citation.title | Clinical and Experimental Allergy | - |
dc.citation.volume | 50 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 585 | - |
dc.citation.endPage | 596 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | NASAL POLYPS | - |
dc.subject.keywordPlus | EMERGING ENDOTYPES | - |
dc.subject.keywordPlus | INTERLEUKIN-33 | - |
dc.subject.keywordPlus | DURATION | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | SMOKING | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordAuthor | age | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | endotype | - |
dc.subject.keywordAuthor | rhinosinusitis | - |
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