The effect of interactions between proteinuria, activity of fibroblast growth factor 23 and serum phosphate on renal progression in patients with chronic kidney disease: a result from the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease study
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyoungnae | - |
dc.contributor.author | Park, Jimin | - |
dc.contributor.author | Nam, Ki Heon | - |
dc.contributor.author | Jhee, Jong Hyun | - |
dc.contributor.author | Yun, Hae-Ryong | - |
dc.contributor.author | Park, Jung Tak | - |
dc.contributor.author | Han, Seung Hyeok | - |
dc.contributor.author | Chung, Wookyung | - |
dc.contributor.author | Oh, Kook-Hwan | - |
dc.contributor.author | Park, Sue Kyung | - |
dc.contributor.author | Kim, Soo Wan | - |
dc.contributor.author | Kang, Shin-Wook | - |
dc.contributor.author | Choi, Kyu Hun | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Yoo, Tae-Hyun | - |
dc.date.accessioned | 2021-08-11T08:37:26Z | - |
dc.date.available | 2021-08-11T08:37:26Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 0931-0509 | - |
dc.identifier.issn | 1460-2385 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/3055 | - |
dc.description.abstract | Background. Recent experimental study reported that proteinuria increases serum phosphate by decreasing biologic activity of fibroblast growth factor 23 (FGF-23). We examined this relationship in a large chronic kidney disease (CKD) cohort and evaluated the combined effect of proteinuria, FGF-23 activity and serum phosphate on CKD progression. Methods. The activity of FGF-23, measured by the fractional excretion of phosphate (FEP)/FGF-23 ratio, was compared according to the degree of proteinuria in 1909 patients with CKD. Primary outcome was CKD progression defined as >= 50% decline of estimated glomerular filtration rate, doubling of serum creatinine and start of dialysis. Results. There was a negative relationship between 24-h urine protein (24-h UP) and FEP/FGF-23 ratio (gamma -0.07; P=0.005). In addition, after matching variables associated with serum phosphate, patients with more proteinuria had higher serum phosphate (P<0.001) and FGF-23 (P=0.012), and lower FEP/FGF-23 ratio (P=0.007) compared with those with less proteinuria. In the matched cohort, low FEP/FGF-23 ratio was an independent risk factor for CKD progression (hazard ratio 0.87 per 1 log increase; 95% confidence interval 0.79-0.95; P=0.002), and there was significant interaction between 24-h UP and FEP/FGF-23 ratio (P=0.039). Furthermore, 24-h UP and serum phosphate also had a significant interaction on CKD progression (P<0.001). Conclusions. Proteinuria is associated with decreased biologic activity of FGF-23 and increased serum phosphate. Furthermore, diminished activity of FGF23 is an independent risk factor for renal progression in proteinuric CKD patients. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Oxford University Press | - |
dc.title | The effect of interactions between proteinuria, activity of fibroblast growth factor 23 and serum phosphate on renal progression in patients with chronic kidney disease: a result from the KoreaN cohort study for Outcome in patients With Chronic Kidney Disease study | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1093/ndt/gfy403 | - |
dc.identifier.scopusid | 2-s2.0-85081043466 | - |
dc.identifier.wosid | 000518551100012 | - |
dc.identifier.bibliographicCitation | Nephrology Dialysis Transplantation, v.35, no.3, pp 438 - 446 | - |
dc.citation.title | Nephrology Dialysis Transplantation | - |
dc.citation.volume | 35 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 438 | - |
dc.citation.endPage | 446 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | BLOOD-PRESSURE CONTROL | - |
dc.subject.keywordPlus | CARDIOVASCULAR OUTCOMES | - |
dc.subject.keywordPlus | PLASMA PHOSPHATE | - |
dc.subject.keywordPlus | RISK-FACTOR | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | PHOSPHORUS | - |
dc.subject.keywordPlus | PREDICTOR | - |
dc.subject.keywordPlus | EXCRETION | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | DIET | - |
dc.subject.keywordAuthor | chronic kidney disease | - |
dc.subject.keywordAuthor | FGF-23 | - |
dc.subject.keywordAuthor | phosphate | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | proteinuria | - |
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