Minor Glomerular Abnormalities are Associated with Deterioration of Long-Term Kidney Function and Mitochondrial Injury
DC Field | Value | Language |
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dc.contributor.author | Yu, Byung Chul | - |
dc.contributor.author | Cho, Nam-Jun | - |
dc.contributor.author | Park, Samel | - |
dc.contributor.author | Kim, Hyoungnae | - |
dc.contributor.author | Gil, Hyo-Wook | - |
dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Kwon, Soon Hyo | - |
dc.contributor.author | Jeon, Jin Seok | - |
dc.contributor.author | Noh, Hyunjin | - |
dc.contributor.author | Han, Dong Cheol | - |
dc.contributor.author | Moon, Ahrim | - |
dc.contributor.author | Park, Su Jung | - |
dc.contributor.author | Kim, Jin Kuk | - |
dc.contributor.author | Hwang, Seung Duk | - |
dc.contributor.author | Choi, Soo Jeong | - |
dc.contributor.author | Park, Moo Yong | - |
dc.date.accessioned | 2021-08-11T08:39:01Z | - |
dc.date.available | 2021-08-11T08:39:01Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/3234 | - |
dc.description.abstract | Minor glomerular abnormalities (MGAs) are unclassified glomerular lesions indicated by the presence of minor structural abnormalities that are insufficient for a specific pathological diagnosis. The long-term clinical outcomes and pathogenesis have not been examined. We hypothesized that MGAs would be associated with the deterioration of long-term kidney function and increased urinary mitochondrial DNA (mtDNA) copy numbers. We retrospectively enrolled patients with MGAs, age-/sex-/estimated glomerular filtration rate (eGFR)-matched patients with immunoglobulin A nephropathy (IgAN), and similarly matched healthy controls (MHCs; n = 49 each). We analyzed the time x group interaction effects of the eGFR and compared mean annual eGFR decline rates between the groups. We prospectively enrolled patients with MGAs, age- and sex-matched patients with IgAN, and MHCs (n = 15 each) and compared their urinary mtDNA copy numbers. Compared to the MHC group, the MGA and IgAN groups displayed differences in the time x group effects of eGFR, higher mean annual rates of eGFR decline, and higher urinary mtDNA copy numbers; however, these groups did not significantly differ from each other. The results indicate that MGAs are associated with deteriorating long-term kidney function, and mitochondrial injury, despite few additional pathological changes. We suggest that clinicians conduct close long-term follow-up of patients with MGAs. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Minor Glomerular Abnormalities are Associated with Deterioration of Long-Term Kidney Function and Mitochondrial Injury | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/jcm9010033 | - |
dc.identifier.scopusid | 2-s2.0-85106241062 | - |
dc.identifier.wosid | 000515388400033 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Medicine, v.9, no.1 | - |
dc.citation.title | Journal of Clinical Medicine | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | IGA NEPHROPATHY | - |
dc.subject.keywordPlus | OXFORD CLASSIFICATION | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | PROTEINURIA | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordAuthor | glomerular filtration rate | - |
dc.subject.keywordAuthor | glomerulonephritis | - |
dc.subject.keywordAuthor | minor glomerular abnormalities | - |
dc.subject.keywordAuthor | mitochondrial injury | - |
dc.subject.keywordAuthor | urinary mitochondrial DNA | - |
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