Korean Children and Adolescents with Crohn's Disease Are More Likely to Present with Perianal Fistulizing Disease at Diagnosis Compared to Their European Counterparts
DC Field | Value | Language |
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dc.contributor.author | Kang, Ben | - |
dc.contributor.author | Kim, Jung Eun | - |
dc.contributor.author | Jung, Jae Hun | - |
dc.contributor.author | Choe, Jae Young | - |
dc.contributor.author | Kim, Mi Jin | - |
dc.contributor.author | Choe, Yon Ho | - |
dc.contributor.author | Kim, Seung | - |
dc.contributor.author | Koh, Hong | - |
dc.contributor.author | Lee, Yoo Min | - |
dc.contributor.author | Lee, Jee Hyun | - |
dc.contributor.author | Lee, Yoon | - |
dc.contributor.author | Lee, Ji-Hyuk | - |
dc.contributor.author | Lee, Hae Jeong | - |
dc.contributor.author | Jang, Hyo-Jeong | - |
dc.contributor.author | Choi, Youjin | - |
dc.contributor.author | Choi, So Yoon | - |
dc.contributor.author | Kim, Ju Young | - |
dc.contributor.author | Choe, Byung-Ho | - |
dc.date.accessioned | 2021-08-11T08:39:06Z | - |
dc.date.available | 2021-08-11T08:39:06Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 2234-8646 | - |
dc.identifier.issn | 2234-8840 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/3252 | - |
dc.description.abstract | Purpose: We aimed to investigate the disease phenotype of Korean pediatric Crohn's disease (CD) patients at diagnosis according to the Paris classification by comparison with patients from the European multicenter 5-years recruitment of children with newly developed IBD (EUROKIDS registry). Methods: Korean children and adolescents who had been newly diagnosed with CD at the age of <18 years during 2013-2016 were included in this multicenter retrospective study. Disease phenotype at diagnosis was classified according to the Paris classification, and compared with the published data from the EUROKIDS study. Results: A total of 255 patients were included. The median diagnosis age was 14.7 years (range, 0.8-17.9 years). No significant difference was observed in male-to-female ratio with EUROKIDS (1.9:1 vs. 1.45:1, p=0.062). The proportion of children aged <10 years was significantly lower in Koreans (7.1% vs. 19.6%, p<0.001). Colonic disease was less prominent (10.0% vs. 27.3%, p<0.001), while upper GI involvement was more prominent in Korean children (59.3% vs. 46.2%, p<0.001). The proportion with perianal fistulizing disease at diagnosis was significantly higher in Korean patients (44.8% vs. 8.2%, p<0.001). A separate analysis of Korean patients revealed that perianal fistulizing disease at diagnosis was positively associated with male sex and body mass index z-score (odds ratio [OR]=2.12, 95% confidence interval [CI]=1.20-3.76, p=0.010; and OR=1.29, 95% CI=1.05-1.58, p=0.015, respectively). Conclusion: Approximately half of pediatric CD patients in Korea present with perianal fistulas and/or abscesses at diagnosis, which is a distinct feature of CD in Korean children and adolescents compared to their European counterparts. An underlying genetic difference between ethnicities may play a role in this expression of different phenotypes in pediatric CD. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한소아소화기영양학회 | - |
dc.title | Korean Children and Adolescents with Crohn's Disease Are More Likely to Present with Perianal Fistulizing Disease at Diagnosis Compared to Their European Counterparts | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5223/pghn.2020.23.1.49 | - |
dc.identifier.scopusid | 2-s2.0-85079369334 | - |
dc.identifier.wosid | 000507574800005 | - |
dc.identifier.bibliographicCitation | Pediatric Gastroenterology, Hepatology & Nutrition, v.23, no.1, pp 49 - 62 | - |
dc.citation.title | Pediatric Gastroenterology, Hepatology & Nutrition | - |
dc.citation.volume | 23 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 49 | - |
dc.citation.endPage | 62 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002551676 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | esci | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | LONG-TERM OUTCOMES | - |
dc.subject.keywordPlus | PHENOTYPE | - |
dc.subject.keywordPlus | DEFINITION | - |
dc.subject.keywordPlus | TRENDS | - |
dc.subject.keywordAuthor | Crohn disease | - |
dc.subject.keywordAuthor | Fistula | - |
dc.subject.keywordAuthor | Abscess | - |
dc.subject.keywordAuthor | Paris | - |
dc.subject.keywordAuthor | Classification | - |
dc.subject.keywordAuthor | Phenotype | - |
dc.subject.keywordAuthor | Korea | - |
dc.subject.keywordAuthor | Europe | - |
dc.subject.keywordAuthor | Pediatrics | - |
dc.subject.keywordAuthor | Inflammatory bowel disease | - |
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