Particulate matter at third trimester and respiratory infection in infants, modified by GSTM1
DC Field | Value | Language |
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dc.contributor.author | Yang, Song-I | - |
dc.contributor.author | Kim, Hyo-Bin | - |
dc.contributor.author | Kim, Hwan-Cheol | - |
dc.contributor.author | Lee, So-Yeon | - |
dc.contributor.author | Kang, Mi-Jin | - |
dc.contributor.author | Cho, Hyun-Ju | - |
dc.contributor.author | Yoon, Jisun | - |
dc.contributor.author | Jung, Sungsu | - |
dc.contributor.author | Lee, Eun | - |
dc.contributor.author | Yang, Hyeon-Jong | - |
dc.contributor.author | Ahn, Kangmo | - |
dc.contributor.author | Kim, Kyung Won | - |
dc.contributor.author | Shin, Youn Ho | - |
dc.contributor.author | Suh, Dong In | - |
dc.contributor.author | Hong, Soo-Jong | - |
dc.date.accessioned | 2021-08-11T08:39:13Z | - |
dc.date.available | 2021-08-11T08:39:13Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 8755-6863 | - |
dc.identifier.issn | 1099-0496 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/3276 | - |
dc.description.abstract | Objectives To investigate the association between particulate matter with an aerodynamic diameter of less than 2.5 mu m (PM2.5) exposure during each trimester of pregnancy and development of lower respiratory tract infections (LRTIs) during the first 3 years of life and whether GSTM1 gene polymorphisms modify these effects. Methods This study included 1,180 mother-child pairs from the Cohort for Childhood Origin of Asthma and allergic diseases. The PM2.5 levels during pregnancy were estimated by residential address using land-use regression models based on a national monitoring system. A diagnosis of LRTIs was based on a parental report of a physician's diagnosis. Real-time polymerase chain reaction was used for GSTM1 genotyping. Results Higher PM2.5 exposure during the third trimester was associated with LRTIs at 1 year of age (aRR, 1.06; 95% CI, 1.00-1.13). This result did not change after adjusting for PM2.5 exposures during the first and second trimesters (aRR, 1.06; 95% CI, 0.99-1.13). This association was significant after adjusting for PM2.5 exposures during first year of age (aRR, 1.08; 95% CI, 1.02-1.15) and exposures to NO2 and ozone at the third trimester (aRR, 1.07; 95% CI, 1.00-1.16). In addition, PM2.5 exposure during the third trimester increased the risk of LRTIs at 1 year of age in cases with the GSTM1 null genotype (aRR, 1.26; 95% CI, 1.01-1.57; P for interaction .20). Conclusion Higher PM2.5 exposure during the third trimester of pregnancy may increase the susceptibility to LRTIs at 1 year of age. This effect is modified by GSTM1 gene polymorphisms. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Particulate matter at third trimester and respiratory infection in infants, modified by GSTM1 | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/ppul.24575 | - |
dc.identifier.scopusid | 2-s2.0-85075252393 | - |
dc.identifier.wosid | 000497203600001 | - |
dc.identifier.bibliographicCitation | Pediatric Pulmonology, v.55, no.1, pp 245 - 253 | - |
dc.citation.title | Pediatric Pulmonology | - |
dc.citation.volume | 55 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 245 | - |
dc.citation.endPage | 253 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | AIR-POLLUTION EXPOSURE | - |
dc.subject.keywordPlus | DIESEL EXHAUST PARTICLES | - |
dc.subject.keywordPlus | LUNG DEVELOPMENT | - |
dc.subject.keywordPlus | SMOKE EXPOSURE | - |
dc.subject.keywordPlus | TOBACCO-SMOKE | - |
dc.subject.keywordPlus | CORD | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | PREGNANCY | - |
dc.subject.keywordPlus | LIFE | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordAuthor | GSTM1 | - |
dc.subject.keywordAuthor | particulate matter | - |
dc.subject.keywordAuthor | prenatal | - |
dc.subject.keywordAuthor | respiratory tract infections | - |
dc.subject.keywordAuthor | third trimester | - |
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