Effects of argon and nitrogen plasma pulses on the skin and skin appendages in an in vivo animal model
- Authors
- Kim, Heesu; Kim, Hyun-Jo; Kim, Hee Kyung; Hong, Jeong Yeon; Cho, Sung Bin
- Issue Date
- Jan-2020
- Publisher
- Blackwell Publishing Inc.
- Keywords
- argon; nitrogen; plasma; rat; skin; skin appendage
- Citation
- Skin Research and Technology, v.26, no.1, pp 81 - 90
- Pages
- 10
- Journal Title
- Skin Research and Technology
- Volume
- 26
- Number
- 1
- Start Page
- 81
- End Page
- 90
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/3277
- DOI
- 10.1111/srt.12767
- ISSN
- 0909-752X
1600-0846
- Abstract
- Background For medical purposes, plasma can be generated from inert gaseous sources in a device by ultra-high-frequency generators and emitted to target tissue at a pulse duration in the milliseconds. Objective To evaluate argon and nitrogen plasma pulse-induced tissue reactions in the skin and skin appendages of an in vivo animal model. Methods Argon and nitrogen plasma pulses were non-invasively delivered to in vivo rat skin at various experimental settings. Specimens were histologically evaluated following hematoxylin and eosin and Masson's trichrome staining. Results At low-energy settings of 1.0, 1.5, and 2.0 J, nitrogen plasma treatments generated noticeable tissue coagulation at the depths of 31.5 +/- 8.3, 94.9 +/- 16.9, and 171.6 +/- 19.7 mu m, respectively, at Day 0. At high-energy settings of 2.5 and 3.0 J, nitrogen plasma treatments generated marked tissue coagulation at the depths of 381.7 +/- 33.6 mu m and 456.3 +/- 75.7 mu m, respectively, at Day 0. Conclusions Treatment with argon plasma induces microscopic changes in the epidermis, dermis, and sebaceous glands without generating excessive thermal injury, whereas that with nitrogen plasma elicits energy-dependent thermal coagulation in the epidermis and dermis with remarkable neocollagenesis.
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Collections - College of Medicine > Department of Pathology > 1. Journal Articles
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