자궁내 인공수정 시술을 받은 고령 난임여성과 비고령 난임여성에서의 임신성공 확률 및 영향 요인의 비교: 2016년 보조생식술 국가지원사업기준

Abstract

Purpose: : The purpose of this study was to evaluate the intrauterine insemination (IUI) success rate and to define the variables for predicting success. Methods: The secondary data analysis was used with data collected from infertile females who underwent IUI in Fertility and IVF (In Vitro Fertilization) clinics, who benefited from the ‘National Medical-aid Program for ART (assisted reproductive technology) in 2016’, in which the data of 34,920 IUI cases were retrospectively reviewed. The primary outcome measure was the clinical pregnancy rate in elderly and young infertile females. Data were analyzed by descriptive statistics, χ2 test and logistic regression. Results: The pregnancy rate was 12.1% (2,095 cases) in elderly infertile females and 15.6% in young infertile females (2,758 cases) (χ2=87.90, p<.001). Using the logistic regression analysis, clinical pregnancy was positively associated with the ovulatory factor (OR=1.48, p<.001) and male factor (OR=1.19, p<.05) in elderly infertile females. It was positively associated with the ovulatory factor (OR=1.30, p=.001) and the peritoneal cavity factor (OR=0.58, p<.05) in young infertile females. Conclusion: Our results indicate that the pregnancy rate in young infertile females was higher than that in old infertile females, and the IUI is the effective option in pregnancies in all ages with infertility due to the ovulatory factor. Additionally, further studies are necessary to fully describe pregnancy experiences for all the infertile females.