Main duct and mixed type intraductal papillary mucinous neoplasms without enhancing mural nodules: Duct diameter of less than 10 mm and segmental dilatation of main pancreatic duct are findings support surveillance rather than immediate surgery
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Hyeon | - |
dc.contributor.author | Song, Tae Jun | - |
dc.contributor.author | Lee, Seung Ok | - |
dc.contributor.author | Park, Chang Hwan | - |
dc.contributor.author | Moon, Jong Ho | - |
dc.contributor.author | Pih, Gyu Young | - |
dc.contributor.author | Oh, Dong Wook | - |
dc.contributor.author | Woo, Sang Myoung | - |
dc.contributor.author | Yang, Yun Jung | - |
dc.contributor.author | Kim, Myung Hwan | - |
dc.date.accessioned | 2021-08-11T09:23:27Z | - |
dc.date.available | 2021-08-11T09:23:27Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1424-3903 | - |
dc.identifier.issn | 1424-3911 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4050 | - |
dc.description.abstract | Objective: The guidelines for pancreatic intraductal papillary mucinous neoplasms (IPMNs) recommend surgical resection of all main-duct (MD) and mixed-type IPMNs in surgically fit patients. We conducted this study to identify the rates of high-grade dysplasia (HGD) and invasive carcinoma according to the morphological features of the main pancreatic duct (MPD) in patients with MD and mixed IPMN. Methods: We performed a retrospective study of 259 patients with histologically proven MD and mixed-type IPMNs who underwent surgery at six academic institutions. Results: The rate of HGD and invasive carcinoma was 11.1% (24/216) in patients without enhancing mural nodules (MNs) and 69.8% (30/43) in patients with MNs. Multivariate analysis showed that MPD diameter of >= 10mm [odds ratio (OR), 2.5; 95% confidence interval (CI), 1.155-5.505; P = 0.02], diffuse MPD dilatation (OR, 3.2; 95% CI, 1.152-8.998; P = 0.02), and presence of enhancing MNs in MPD (OR, 9.6; 95% CI, 3.928-23.833, P < 0.0001) were significant predictors of HGD and invasive carcinoma. Of the 216 patients without enhancing MNs, 79 patients (36.6%) having both segmental MPD dilatation and MPD diameter of <10 mm showed significantly lower rates of HGD and invasive carcinoma (3/79, 3.8%) than patients having both diffuse MPD dilatation and MPD diameter >= 10mm (9/36, 25%, P = 0.001). Conclusions: MD and mixed-type IPMNs having segmental MPD dilatation with MPD dilation <10 mm and no enhancing MNs on imaging showed a significantly lower rate of HGD and invasive carcinoma, and watchful follow-up instead of immediate surgical resection might be possible in these patients. (C) 2019 IAP and EPC. Published by Elsevier B.V. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | S. Karger AG | - |
dc.title | Main duct and mixed type intraductal papillary mucinous neoplasms without enhancing mural nodules: Duct diameter of less than 10 mm and segmental dilatation of main pancreatic duct are findings support surveillance rather than immediate surgery | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.pan.2019.09.010 | - |
dc.identifier.wosid | 000499712300007 | - |
dc.identifier.bibliographicCitation | Pancreatology, v.19, no.8, pp 1054 - 1060 | - |
dc.citation.title | Pancreatology | - |
dc.citation.volume | 19 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1054 | - |
dc.citation.endPage | 1060 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | INTERNATIONAL CONSENSUS GUIDELINES | - |
dc.subject.keywordPlus | TREATMENT STRATEGY | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | INVOLVEMENT | - |
dc.subject.keywordPlus | PREDICTORS | - |
dc.subject.keywordPlus | MALIGNANCY | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | IPMN | - |
dc.subject.keywordAuthor | Main duct intraductal papillary mucinous neoplasms | - |
dc.subject.keywordAuthor | Mixed type intraductal papillary mucinous neoplasms | - |
dc.subject.keywordAuthor | Mural nodule | - |
dc.subject.keywordAuthor | Pancreatic cancer | - |
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