A comparison study on efficacy, insulin sensitivity and safety of Glimepiride/Metformin fixed dose combination versus glimepiride single therapy on type 2 diabetes mellitus patients with basal insulin therapy
DC Field | Value | Language |
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dc.contributor.author | Yu, Hea Min | - |
dc.contributor.author | Kim, Sang Jin | - |
dc.contributor.author | Chun, Sung Wan | - |
dc.contributor.author | Park, Keun Young | - |
dc.contributor.author | Lim, Dong Mee | - |
dc.contributor.author | Lee, Jong Min | - |
dc.contributor.author | Hong, Jun Hwa | - |
dc.contributor.author | Park, Kang Seo | - |
dc.date.accessioned | 2021-08-11T09:24:24Z | - |
dc.date.available | 2021-08-11T09:24:24Z | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.issn | 1872-8227 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4245 | - |
dc.description.abstract | Aim: The aim of this study was to analyze the efficacy, insulin sensitivity and safety in the event of administering sulfonylurea-based drugs and metformin in combination with basal insulin. Methods: A randomized, open-label, parallel, 16-week trial was conducted across four study centers. The 97 type 2 diabetic patients were selected and randomized into two groups, the insulin glargine plus fixed-dose combination glimepiride 1 mg and metformin 500 mg twice daily group (the G/M group) and the insulin glargine plus glimepiride 4 mg once daily group (the G group). The primary endpoint evaluated was change in HbA1c. The secondary endpoints evaluated were changes in fasting blood glucose (FPG), 2-h post prandial glucose (PPG 2 h), insulin, and C-peptide levels. Results: The G/M group was found to have experienced a significantly greater decrease in HbA1c, as well as PPG 2 h compared to the G group. While no significant intergroup difference was found regarding FPG in the ITT, the G/M group in the PP set experienced a significantly greater decrease in FPG. Conclusion: Comparison of combined therapy consisting of either the G/M group or the G group indicated that both forms of therapy are relatively safe but that the former more effectively decreases blood glucose levels. (C) 2019 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | A comparison study on efficacy, insulin sensitivity and safety of Glimepiride/Metformin fixed dose combination versus glimepiride single therapy on type 2 diabetes mellitus patients with basal insulin therapy | - |
dc.type | Article | - |
dc.publisher.location | 아일랜드 | - |
dc.identifier.doi | 10.1016/j.diabres.2019.107796 | - |
dc.identifier.scopusid | 2-s2.0-85069746621 | - |
dc.identifier.wosid | 000487832100011 | - |
dc.identifier.bibliographicCitation | Diabetes Research and Clinical Practice, v.155 | - |
dc.citation.title | Diabetes Research and Clinical Practice | - |
dc.citation.volume | 155 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | HOMEOSTASIS MODEL ASSESSMENT | - |
dc.subject.keywordPlus | BETA-CELL FUNCTION | - |
dc.subject.keywordPlus | IMPROVED GLYCEMIC CONTROL | - |
dc.subject.keywordPlus | METFORMIN | - |
dc.subject.keywordPlus | SULFONYLUREA | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | MONOTHERAPY | - |
dc.subject.keywordPlus | ADHERENCE | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordAuthor | Type 2 diabetes mellitus | - |
dc.subject.keywordAuthor | Sulfonylurea compounds | - |
dc.subject.keywordAuthor | Metformin | - |
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