Optimal Timing of Simethicone Addition for Bowel Preparation Using Polyethylene Glycol Plus Ascorbic Acid
DC Field | Value | Language |
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dc.contributor.author | Kim, Haewon | - |
dc.contributor.author | Ko, Bong Min | - |
dc.contributor.author | Goong, Hyeon Jeong | - |
dc.contributor.author | Jung, Yun Ho | - |
dc.contributor.author | Jeon, Seong Ran | - |
dc.contributor.author | Kim, Hyun Gun | - |
dc.contributor.author | Lee, Moon Sung | - |
dc.date.accessioned | 2021-08-11T09:24:34Z | - |
dc.date.available | 2021-08-11T09:24:34Z | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.issn | 1573-2568 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4277 | - |
dc.description.abstract | Background Colonic bubbles obscure the colonic mucosa during colonoscopy following bowel preparation with polyethylene glycol plus ascorbic acid (PEG-Asc). Simethicone is used to enhance visualization during colonoscopy. We aimed to determine the optimal timing of simethicone addition to improve bowel preparation using PEG-Asc. Methods This prospective, randomized study enrolled patients undergoing elective colonoscopy from April 2017 to January 2018. They were randomly assigned to one of the following three groups: PEG-Asc only (control) or simethicone addition in the morning on the day of colonoscopy (PEG-S1) or in the evening of the day prior to colonoscopy (PEG-S2). The primary outcome was the quality of colon cleansing, and the secondary outcomes were the adenoma detection rate (ADR), polyp detection rate (PDR), and diminutive (<= 5 mm) ADR. Results In total, 240 patients were randomly allocated to the three groups; six patients were withdrawn. Of the 234 patients evaluated, 78, 79, and 77 were allocated to the control, PEG-S1, and PEG-S2 groups, respectively. The bubble scores of all colonic segments were lowest in the PEG-S2 group. There was no significant difference in ADR or PDR among the three groups. However, the diminutive ADR was significantly higher in the PEG-S2 group compared to the other two groups (control 5.1% vs. PEG-S1 8.9% vs. PEG-S2 20.8%; P = 0.009). Conclusion Addition of simethicone to PEG-Asc at the optimal time prevents the formation of air bubbles and so improves the quality of bowel preparation, especially enhancing diminutive ADR. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Kluwer Academic/Plenum Publishers | - |
dc.title | Optimal Timing of Simethicone Addition for Bowel Preparation Using Polyethylene Glycol Plus Ascorbic Acid | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1007/s10620-019-05599-2 | - |
dc.identifier.scopusid | 2-s2.0-85064252732 | - |
dc.identifier.wosid | 000482238300032 | - |
dc.identifier.bibliographicCitation | Digestive Diseases and Sciences, v.64, no.9, pp 2607 - 2613 | - |
dc.citation.title | Digestive Diseases and Sciences | - |
dc.citation.volume | 64 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2607 | - |
dc.citation.endPage | 2613 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | COLONOSCOPY | - |
dc.subject.keywordPlus | MULTICENTER | - |
dc.subject.keywordAuthor | Simethicone | - |
dc.subject.keywordAuthor | Bowel preparation | - |
dc.subject.keywordAuthor | ADR | - |
dc.subject.keywordAuthor | PEG | - |
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