Long-term durability and safety of fecal microbiota transplantation for recurrent or refractory Clostridioides difficile infection with or without antibiotic exposure
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Christine H. | - |
dc.contributor.author | Chai, Jocelyn | - |
dc.contributor.author | Hammond, Keely | - |
dc.contributor.author | Jeon, Seong Ran | - |
dc.contributor.author | Patel, Yogita | - |
dc.contributor.author | Goldeh, Christiana | - |
dc.contributor.author | Kim, Peter | - |
dc.date.accessioned | 2021-08-11T09:24:37Z | - |
dc.date.available | 2021-08-11T09:24:37Z | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 0934-9723 | - |
dc.identifier.issn | 1435-4373 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4285 | - |
dc.description.abstract | Fecal microbiota transplant (FMT) is a safe and effective treatment for recurrent or refractory Clostridioides (Clostridium) difficile infection (RCDI) in the short term. However, there are a paucity of data on long-term durability and safety of FMT. The aim of this study is to determine the long-term efficacy and safety of FMT for RCDI. Ninety-four patients underwent FMT via retention enema for RCDI between 2008 and 2012 and completed a follow-up questionnaire 4 to 8 years following the last FMT. Of these, 32 were unreachable and 37 were deceased; 23 of the remaining 25 participants completed the survey. No CDI recurrences were reported in patients treated with FMT; 12 of the 23 participants (52.2%) received at least one course of non-CDI antibiotic(s). Nine participants (40.9%) received probiotics and 4 (17.4%) received both non-CDI antibiotics and probiotics. All 23 participants rated their overall health compared with pre-FMT. Current health was considered "much better" in 17 patients (73.9%); "somewhat better" in 3 patients (13.0%); and "about the same" in 3 patients (13.0%). A total of 11 participants (47.8%) reported an increase in weight of more than 5 kg (kg) post-FMT and 9 participants (39.1%) reported no change in weight (+/- 5 kg). Four of the 23 participants (17.4%) reported improvement or resolution (undifferentiated colitis, n = 1; Crohn's disease, n = 2; ulcerative colitis, n = 1) of pre-existing gastrointestinal condition following FMT. Eight of 23 participants (34.8%) experienced new medical condition(s) post-FMT. The long-term efficacy (48-96 months) of FMT for RCDI appears to be durable even after non-CDI antibiotic use. Thirty percent had improvement of their pre-existing medical conditions following FMT; 73.9% reported "much better" overall health following FMT. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer Verlag | - |
dc.title | Long-term durability and safety of fecal microbiota transplantation for recurrent or refractory Clostridioides difficile infection with or without antibiotic exposure | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s10096-019-03602-2 | - |
dc.identifier.scopusid | 2-s2.0-85066985544 | - |
dc.identifier.wosid | 000481757500018 | - |
dc.identifier.bibliographicCitation | European Journal of Clinical Microbiology and Infectious Diseases, v.38, no.9, pp 1731 - 1735 | - |
dc.citation.title | European Journal of Clinical Microbiology and Infectious Diseases | - |
dc.citation.volume | 38 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1731 | - |
dc.citation.endPage | 1735 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | BURDEN | - |
dc.subject.keywordAuthor | Long-term follow-up | - |
dc.subject.keywordAuthor | Fecal microbiota transplantation | - |
dc.subject.keywordAuthor | Recurrent Clostridioides difficile infection | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.