The New Cutoff Value of the Hepatic Venous Pressure Gradient on Predicting Long-Term Survival in Cirrhotic Patients
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Yeob | - |
dc.contributor.author | Suk, Ki Tae | - |
dc.contributor.author | Jeong, Soung Won | - |
dc.contributor.author | Ryu, Tom | - |
dc.contributor.author | Kim, Dong Joon | - |
dc.contributor.author | Baik, Soon Koo | - |
dc.contributor.author | Sohn, Joo Hyun | - |
dc.contributor.author | Jeong, Woo Kyoung | - |
dc.contributor.author | Choi, Eunhee | - |
dc.contributor.author | Jang, Jae Young | - |
dc.contributor.author | Kim, Moon Young | - |
dc.date.accessioned | 2021-08-11T09:24:41Z | - |
dc.date.available | 2021-08-11T09:24:41Z | - |
dc.date.issued | 2019-08-26 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4303 | - |
dc.description.abstract | Background: This study aimed to determine the prognostic role of the categorized hemodynamic stage (HS) based on the hepatic venous pressure gradient (HVPG) in patients with portal hypertension. Methods: Of 1,025 cirrhotic patients who underwent HVPG measurement, data on 572 noncritically-ill patients were collected retrospectively between 2008 and 2013. The following two HS categorizations were used: HS-1 (6-9, 10-12, 13-16, 17-20, and > 20 mmHg; designated as groups 1-5, respectively) and HS-2 (6-12, 13-20, and > 20 mmHg). Clinical characteristics, mortality rates, and prognostic predictors were analyzed according to the categorized HS. Results: During the mean follow-up period of 25 months, 86 (15.0%) patients died. The numbers of deaths in HS-1 groups were 7 (6.3%), 7 (6.9%), 30 (18.0%), 20 (15.6%), and 22 (34.4%), respectively (P < 0.001). However, the traditional HVPG cutoffs of 10 and 16 mmHg did not improve the discrimination of mortality. In contrast, the mortality rates did differ significantly between the three HS-2 groups (P < 0.05). In the multivariate analysis, all models revealed that HS-2 was a common prognostic factor in predicting mortality. The mortality rates increased significantly according to HS-2 in patients with hypoalbuminemia (HVPG, 13-20 mmHg; hazard ratio [HR], 2.54 and HVPG > 20 mmHg; HR, 5.45) and intermediate model for end-stage liver disease (MELD) score (HVPG, 13-20 mmHg; HR, 3.86 and HVPG > 20 mmHg; HR, 8.77; P < 0.05). Conclusion: Categorizing HVPG values according to HS-2 is a useful prognostic modality in patients with portal hypertension and can play an independent role in predicting the prognosis in patients with hypoalbuminemia and an intermediate MELD score. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한의학회 | - |
dc.title | The New Cutoff Value of the Hepatic Venous Pressure Gradient on Predicting Long-Term Survival in Cirrhotic Patients | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3346/jkms.2019.34.e223 | - |
dc.identifier.scopusid | 2-s2.0-85071525375 | - |
dc.identifier.wosid | 000483126700003 | - |
dc.identifier.bibliographicCitation | Journal of Korean Medical Science, v.34, no.33 | - |
dc.citation.title | Journal of Korean Medical Science | - |
dc.citation.volume | 34 | - |
dc.citation.number | 33 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002493219 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | STAGE LIVER-DISEASE | - |
dc.subject.keywordPlus | PROGNOSTIC INDICATORS | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | CLINICAL-USE | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | BIOPSY | - |
dc.subject.keywordAuthor | Cirrhosis | - |
dc.subject.keywordAuthor | Hemodynamics | - |
dc.subject.keywordAuthor | Portal Hypertension | - |
dc.subject.keywordAuthor | Prognosis | - |
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