Clinical profiles of early and tuberculosis-related mortality in South Korea between 2015 and 2017: a cross-sectional study
DC Field | Value | Language |
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dc.contributor.author | Min, Jinsoo | - |
dc.contributor.author | Kim, Ju Sang | - |
dc.contributor.author | Kim, Hyung Woo | - |
dc.contributor.author | Shin, Ah Young | - |
dc.contributor.author | Koo, Hyeon-Kyoung | - |
dc.contributor.author | Lee, Sung-Soon | - |
dc.contributor.author | Kim, Yang-Ki | - |
dc.contributor.author | Shin, Kyeong-Cheol | - |
dc.contributor.author | Chang, Jung Hyun | - |
dc.contributor.author | Chun, Gayoung | - |
dc.contributor.author | Lee, Joosun | - |
dc.contributor.author | Park, Mi Sun | - |
dc.contributor.author | Park, Jae Seuk | - |
dc.date.accessioned | 2021-08-11T09:24:42Z | - |
dc.date.available | 2021-08-11T09:24:42Z | - |
dc.date.issued | 2019-08-22 | - |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4305 | - |
dc.description.abstract | BackgroundAlthough the incidence of tuberculosis (TB) has decreased in South Korea, the mortality rate remains high. TB mortality is a key indicator for TB control interventions. The purpose of this study was to assess early and TB-related mortality during anti-TB treatment and describe the associated clinical characteristics.MethodsA multicenter cross-sectional study was performed across South Korea. Patients with pulmonary TB who died during anti-TB treatment and whose records were submitted to the national TB surveillance system between 2015 and 2017 were enrolled. All TB deaths were categorized based on cause (TB-related or non-TB-related) and timing (early or late). We identified statistical associations using the frequency table, chi-square test, and binary logistic regression.ResultsOf 5595 notifiable mortality cases, 3735 patients with pulmonary TB were included in the analysis. There were 2541 (68.0%) male patients, and 2935 (78.6%) mortality cases were observed in patients older than 65years. There were 944 (25.3%) cases of TB-related death and 2545 (68.1%) cases of early death. Of all cases, 187 (5.0%) patients were diagnosed post-mortem and 38 (1.0%) patients died on the first day of treatment. Low body mass index (adjusted odds ratio (aOR)=1.26; 95% confidence interval (CI)=1.08-1.48), no reported illness (aOR=1.36; 95% CI=1.10-1.68), bilateral disease on chest X-ray (aOR=1.30; 95% CI=1.11-1.52), and positive acid-fast bacilli smear result (aOR=1.30; 95% CI=1.11-1.52) were significantly associated with early death, as well as TB-related death. Acute respiratory failure was the most common mode of non-TB-related death. Malignancy was associated with both late (aOR=0.71; 95% CI=0.59-0.89) and non-TB-related (aOR=0.35; 95% CI=0.26-0.46) death.ConclusionsA high proportion of TB death was observed in elderly patients and attributed to non-TB-related causes. Many TB-related deaths occurred during the intensive phase, particularly within the first month. Further studies identifying risk factors for different causes of TB death at different phases of anti-TB treatment are warranted for early targeted intervention in order to reduce TB mortality. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BioMed Central | - |
dc.title | Clinical profiles of early and tuberculosis-related mortality in South Korea between 2015 and 2017: a cross-sectional study | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1186/s12879-019-4365-9 | - |
dc.identifier.scopusid | 2-s2.0-85071233741 | - |
dc.identifier.wosid | 000483312400001 | - |
dc.identifier.bibliographicCitation | BMC Infectious Diseases, v.19, no.1 | - |
dc.citation.title | BMC Infectious Diseases | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | PATIENT | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | TIME | - |
dc.subject.keywordAuthor | Private-public mix | - |
dc.subject.keywordAuthor | PPM | - |
dc.subject.keywordAuthor | Death | - |
dc.subject.keywordAuthor | Elderly | - |
dc.subject.keywordAuthor | Korea | - |
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