Cur2004-8, a synthetic curcumin derivative, extends lifespan and modulates age-related physiological changes in Caenorhabditis elegans
DC Field | Value | Language |
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dc.contributor.author | Kim, Bo-Kyoung | - |
dc.contributor.author | Kim, Sung-A | - |
dc.contributor.author | Baek, Sun-Mi | - |
dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Lee, Eun Soo | - |
dc.contributor.author | Chung, Choon Hee | - |
dc.contributor.author | Ahn, Chan Mug | - |
dc.contributor.author | Park, Sang-Kyu | - |
dc.date.accessioned | 2021-08-11T09:24:47Z | - |
dc.date.available | 2021-08-11T09:24:47Z | - |
dc.date.issued | 2019-08 | - |
dc.identifier.issn | 1881-7831 | - |
dc.identifier.issn | 1881-784X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4322 | - |
dc.description.abstract | Curcumin, a compound found in Indian yellow curry, is known to possess various biological activities, including anti-oxidant, anti-inflammatory, and anti-cancer activities. Cur2004-8 is a synthetic curcumin derivative having symmetrical bis-alkynyl pyridines that shows a strong anti-angiogenic activity. In the present study, we examined the effect of dietary supplementation with Cur2004-8 on response to environmental stresses and aging using Caenorhabditis elegans as a model system. Dietary intervention with Cur2004-8 significantly increased resistance of C. elegans to oxidative stress. Its anti-oxidative-stress effect was greater than curcumin. However, response of C. elegans to heat stress or ultraviolet irradiation was not significantly affected by Cur2004-8. Next, we examined the effect of Cur2004-8 on aging. Cur2004-8 significantly extended both mean and maximum lifespan, accompanying a shift in time-course distribution of progeny production. Age-related decline in motility was also delayed by supplementation with Cur2004-8. In addition, Cur2004-8 prevented amyloid-beta-induced toxicity in Alzheimer's disease model animals which required a forkhead box (FOXO) transcription factor DAF-16. Dietary supplementation with Cur2004-8 also reversed the increase of mortality observed in worms treated with high-glucose-diet. These results suggest that Cur2004-8 has higher anti-oxidant and anti-aging activities than curcumin. It can be used for the development of novel anti-aging product. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | International Advancement Center for Medicine & Health Research Co., Ltd. (IACMHR Co., Ltd.) | - |
dc.title | Cur2004-8, a synthetic curcumin derivative, extends lifespan and modulates age-related physiological changes in Caenorhabditis elegans | - |
dc.type | Article | - |
dc.publisher.location | 일본 | - |
dc.identifier.doi | 10.5582/ddt.2019.01057 | - |
dc.identifier.wosid | 000486638100004 | - |
dc.identifier.bibliographicCitation | Drug discoveries & therapeutics, v.13, no.4, pp 198 - 206 | - |
dc.citation.title | Drug discoveries & therapeutics | - |
dc.citation.volume | 13 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 198 | - |
dc.citation.endPage | 206 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | esci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | SUPEROXIDE-DISMUTASE | - |
dc.subject.keywordPlus | D-GALACTOSE | - |
dc.subject.keywordPlus | VITAMIN-E | - |
dc.subject.keywordPlus | EXTENSION | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | CATALASE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | PROTEOTOXICITY | - |
dc.subject.keywordPlus | REPRODUCTION | - |
dc.subject.keywordAuthor | Curcumin | - |
dc.subject.keywordAuthor | Cur2004-8 | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | aging | - |
dc.subject.keywordAuthor | Caenorhabditis elegans | - |
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