Association between Homocysteine Levels and Psoriasis: A Meta-Analysis
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung Eun | - |
dc.contributor.author | Lee, Ho Jung | - |
dc.contributor.author | Lee, Jong Suk | - |
dc.contributor.author | Whang, Kyu Uang | - |
dc.contributor.author | Park, Young Lip | - |
dc.contributor.author | Lee, Sung Yul | - |
dc.contributor.author | Kim, Hyun Jung | - |
dc.date.accessioned | 2021-08-11T09:43:28Z | - |
dc.date.available | 2021-08-11T09:43:28Z | - |
dc.date.issued | 2019-08 | - |
dc.identifier.issn | 1013-9087 | - |
dc.identifier.issn | 2005-3894 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4359 | - |
dc.description.abstract | Background: Psoriasis is a multifactorial disease associated with an increased risk for metabolic syndrome and cardiovascular diseases. Elevated levels of homocysteine (Hcy) are a marker of cardiovascular risk. Several studies have evaluated the associations between psoriasis and Hcy levels; however, the results remain inconclusive. Objective: We performed a systematic review of the literature and a meta-analysis to better understand the relationship between psoriasis and Hcy. Methods: Five scientific databases (MEDLI NE, Embase, Cochrane Library, Scopus, and Web of Science) were searched to identify relevant studies. A review of 307 publications identified 16 studies that directly assessed plasma levels of Hcy in psoriasis patients. Results: A total of 16 studies including 2,091 subjects were included in the meta-analysis. Hcy levels were significantly higher in psoriasis patients relative to healthy controls (weighted mean difference [WMD], 3.30; 95% confidence interval [CI], 1.58 similar to 5.02; I-2 = 82.1%). Subgroup analyses revealed that patients with higher mean psoriasis area severity index (PASI) scores (PASI> 10) had significantly higher Hcy levels compared to healthy controls (WMD, 4.1 7; 95% CI, 1.18 similar to 7.16; I-2 =88.3%), whereas patients with lower mean PASI scores (PASI <= 10) had not (WMD, 0.76; 95% CI, -1.84 similar to 3.35; I-2 = 72.2%). Conclusion: This meta-analysis found that psoriasis patients, in particular those with PASI > 10, had significantly higher Hcy levels compared to healthy controls. Further research is needed to determine the association between Hcy levels and psoriasis severity. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한피부과학회 | - |
dc.title | Association between Homocysteine Levels and Psoriasis: A Meta-Analysis | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5021/ad.2019.31.4.378 | - |
dc.identifier.scopusid | 2-s2.0-85069192471 | - |
dc.identifier.wosid | 000475301000003 | - |
dc.identifier.bibliographicCitation | Annals of Dermatology, v.31, no.4, pp 378 - 386 | - |
dc.citation.title | Annals of Dermatology | - |
dc.citation.volume | 31 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 378 | - |
dc.citation.endPage | 386 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002488460 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | FOLIC-ACID LEVELS | - |
dc.subject.keywordPlus | PLASMA HOMOCYSTEINE | - |
dc.subject.keywordPlus | SYSTEMIC INFLAMMATION | - |
dc.subject.keywordPlus | CARDIOVASCULAR RISK | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | VASCULAR-DISEASE | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordPlus | FOLATE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PLAQUE | - |
dc.subject.keywordAuthor | Homocysteine | - |
dc.subject.keywordAuthor | Meta-analysis | - |
dc.subject.keywordAuthor | Psoriasis | - |
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