Long-term effect of medium cut-off dialyzer on middle uremic toxins and cell-free hemoglobin
DC Field | Value | Language |
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dc.contributor.author | Cho, Nam-Jun | - |
dc.contributor.author | Park, Samel | - |
dc.contributor.author | Islam, Md Imtiazul | - |
dc.contributor.author | Song, Ho-Yeon | - |
dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Gil, Hyo-Wook | - |
dc.date.accessioned | 2021-08-11T09:43:31Z | - |
dc.date.available | 2021-08-11T09:43:31Z | - |
dc.date.issued | 2019-07-26 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4374 | - |
dc.description.abstract | The medium cut-off (MCO) dialyzer has shown good clearance of large middle molecules, but its long-term effects are unclear. We investigated whether MCO hemodialysis (HD) over one year could reduce middle molecule levels and cell-free hemoglobin (CFH), without albumin loss. A prospective cohort study in 57 hemodialysis patients was conducted. The patients were assigned to the MCO dialyzer group or the high-flux dialyzer group, according to the HD machine they used. The reduction ratio (RR) and one-year changes in small and middle molecules and CFH were analyzed. Over a 12-month follow-up, MCO HD did not reduce the serum levels of middle molecules (lambda free light chain [FLC], from 135.7 +/- 39.9 to 132.0 +/- 39.1 mg/L; kappa FLC, from 168.2 +/- 58.5 to 167.7 +/- 65.8 mg/L; beta 2-microglobulin, from 25.6 +/- 9.6 to 28.4 +/- 4.8 mg/L) or albumin (from 3.96 +/- 0.31 to 3.94 +/- 0.37 g/dL). MCO HD provided excellent RR of lambda FLC (49.3 +/- 10.3%), kappa FLC (69.6 +/- 10.4%) and beta 2-microglobulin (80.9 +/- 7.3%), compared to high-flux HD. CFH was also removed well during an MCO HD session (RR of CPH, 85.5 [78.7-97.3] %), but long-term change was not significant (from 57.8 [46.2-79.1] to 62.0 [54.6-116.7] mg/L). The MCO dialyzer can be used effectively and safely in conventional HD settings, but long-term effects on large middle molecules and CFH were not significant. Further studies are needed to verify clinical benefits of the MCO dialyzer. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Public Library of Science | - |
dc.title | Long-term effect of medium cut-off dialyzer on middle uremic toxins and cell-free hemoglobin | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1371/journal.pone.0220448 | - |
dc.identifier.scopusid | 2-s2.0-85069967271 | - |
dc.identifier.wosid | 000484979500037 | - |
dc.identifier.bibliographicCitation | PLoS ONE, v.14, no.7 | - |
dc.citation.title | PLoS ONE | - |
dc.citation.volume | 14 | - |
dc.citation.number | 7 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | NITRIC-OXIDE BIOAVAILABILITY | - |
dc.subject.keywordPlus | HIGH-FLUX DIALYZERS | - |
dc.subject.keywordPlus | DIALYSIS PATIENTS | - |
dc.subject.keywordPlus | HEMODIALYSIS | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | REMOVAL | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | MCO | - |
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