Natural course of fatty liver in 36,195 South Korean adults
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sung, Ki-Chul | - |
dc.contributor.author | Lee, Mi-Yeon | - |
dc.contributor.author | Lee, Jong-Young | - |
dc.contributor.author | Lee, Sung-Ho | - |
dc.contributor.author | Kim, Yong-Bum | - |
dc.contributor.author | Song, Won-Jun | - |
dc.contributor.author | Huh, Ji-Hye | - |
dc.contributor.author | Park, Jin-Sun | - |
dc.contributor.author | Shin, Jeong-Hun | - |
dc.contributor.author | Seo, Mi Hae | - |
dc.contributor.author | Kim, Seong-Hwan | - |
dc.contributor.author | Kim, Sun H. | - |
dc.date.accessioned | 2021-08-11T09:43:32Z | - |
dc.date.available | 2021-08-11T09:43:32Z | - |
dc.date.issued | 2019-07-15 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4380 | - |
dc.description.abstract | Nonalcoholic fatty liver disease (NAFLD) is the most common cause of liver disease, and yet the natural course remains unclear. Study population included 36,195 individuals who participated in a health-screening program and diagnosed with fatty liver by abdominal ultrasound. Participants were provided written information regarding fatty liver and advised to make lifestyle changes. Ultrasound was repeated after at least 6 months. After a mean follow up of 4.9 years (+/- 3.4), 19.6% resolved their fatty liver. Individuals who resolved were more likely female (22.9% vs. 12.3%), thinner (body mass index [BMI], 25.2 +/- 2.7 vs. 26 +/- 2.7), and with lower HOMA-IR (1.4 vs. 1.7) (P.70.001). Decrease in BMI predicted resolution of fatty liver with 42% of those in the top quartile of BMI decline resolving compared with 5.7% in the lowest quartile (odds ratio [OR] (95% confidence interval [CI]) 15.65 (14.13-17.34), P < 0.001)). Baseline HOMA-IR also predicted resolution with those in the top quartile (most insulin resistant) being least likely to resolve (12%) vs. those in the lowest quartile (25%) (OR 0.36 [0.31-0.42], P < 0.001). Fatty liver disease is persistent. Individuals with higher degree of insulin resistance are also the most likely to have persistent steatosis at follow up. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Natural course of fatty liver in 36,195 South Korean adults | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1038/s41598-019-44738-7 | - |
dc.identifier.wosid | 000475467000001 | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.9 | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | NONALCOHOLIC STEATOHEPATITIS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | fatty liver | - |
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