Adipose Tissue-Derived Signatures for Obesity and Type 2 Diabetes: Adipokines, Batokines and MicroRNAs
DC Field | Value | Language |
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dc.contributor.author | Lee, Min-Woo | - |
dc.contributor.author | Lee, Mihye | - |
dc.contributor.author | Oh, Kyoung-Jin | - |
dc.date.accessioned | 2021-08-11T09:43:52Z | - |
dc.date.available | 2021-08-11T09:43:52Z | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4481 | - |
dc.description.abstract | Obesity is one of the main risk factors for type 2 diabetes mellitus (T2DM). It is closely related to metabolic disturbances in the adipose tissue that primarily functions as a fat reservoir. For this reason, adipose tissue is considered as the primary site for initiation and aggravation of obesity and T2DM. As a key endocrine organ, the adipose tissue communicates with other organs, such as the brain, liver, muscle, and pancreas, for the maintenance of energy homeostasis. Two different types of adipose tissues-the white adipose tissue (WAT) and brown adipose tissue (BAT)-secrete bioactive peptides and proteins, known as adipokines and batokines, respectively. Some of them have beneficial anti-inflammatory effects, while others have harmful inflammatory effects. Recently, exosomal microRNAs (miRNAs) were identified as novel adipokines, as adipose tissue-derived exosomal miRNAs can affect other organs. In the present review, we discuss the role of adipose-derived secretory factors-adipokines, batokines, and exosomal miRNA-in obesity and T2DM. It will provide new insights into the pathophysiological mechanisms involved in disturbances of adipose-derived factors and will support the development of adipose-derived factors as potential therapeutic targets for obesity and T2DM. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Adipose Tissue-Derived Signatures for Obesity and Type 2 Diabetes: Adipokines, Batokines and MicroRNAs | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/jcm8060854 | - |
dc.identifier.wosid | 000475349300098 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Medicine, v.8, no.6 | - |
dc.citation.title | Journal of Clinical Medicine | - |
dc.citation.volume | 8 | - |
dc.citation.number | 6 | - |
dc.type.docType | Review | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | ACYLATION-STIMULATING PROTEIN | - |
dc.subject.keywordPlus | ACID-BINDING PROTEIN | - |
dc.subject.keywordPlus | BONE MORPHOGENETIC PROTEIN-7 | - |
dc.subject.keywordPlus | FIBROBLAST GROWTH FACTOR-21 | - |
dc.subject.keywordPlus | REGULATES INSULIN-SECRETION | - |
dc.subject.keywordPlus | SERUM VASPIN CONCENTRATIONS | - |
dc.subject.keywordPlus | ANGIOPOIETIN-LIKE PROTEIN | - |
dc.subject.keywordPlus | ANTIGEN-PRESENTING CELLS | - |
dc.subject.keywordPlus | PROSTAGLANDIN D SYNTHASE | - |
dc.subject.keywordPlus | HIGH-FAT DIET | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | type 2 diabetes mellitus | - |
dc.subject.keywordAuthor | adipokines | - |
dc.subject.keywordAuthor | batokines | - |
dc.subject.keywordAuthor | exosomal miRNAs | - |
dc.subject.keywordAuthor | potential therapeutic targets | - |
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