Characteristics of blood tests in patients with acute cerebral infarction who developed symptomatic intracranial hemorrhage after intravenous administration of recombinant tissue plasminogen activator
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Chungjo | - |
dc.contributor.author | Na, Ji Ung | - |
dc.contributor.author | Lee, Jang Hee | - |
dc.contributor.author | Han, Sang Kuk | - |
dc.contributor.author | Choi, Pil Cho | - |
dc.contributor.author | Lee, Young Hwan | - |
dc.contributor.author | Park, Sang O. | - |
dc.contributor.author | Shin, Dong Hyuk | - |
dc.date.accessioned | 2021-08-11T09:43:53Z | - |
dc.date.available | 2021-08-11T09:43:53Z | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 2383-4625 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4489 | - |
dc.description.abstract | Objective Patients suspected as having acute ischemic stroke usually undergo blood tests, including coagulation-related indexes, because thrombocytopenia and coagulopathy are contraindications for recombinant tissue plasminogen activator (rtPA) administration. We aimed to identify blood test indexes associated with symptomatic intracranial hemorrhage (sICH) in patients with acute ischemic stroke who received intravenous rtPA. Methods This retrospective observational study included patients diagnosed with acute ischemic stroke who were treated with intravenous rtPA at the emergency department of a tertiary hospital in Seoul between February 2008 and January 2018. Blood test indexes were compared between the sICH and non-sICH groups. Logistic regression and receiver-operating characteristic curve analyses were performed. Results In this study, 375 patients were finally included. Of 375 patients, 42 (11.2%) showed new intracranial hemorrhage on follow-up brain computed tomography, of whom 14 (3.73%) had sICH. Platelet count, aspartate aminotransferase and lactate dehydrogenase levels were significantly different between the sICH and non-sICH groups, and platelet count showed statistical significance in the regression analysis. Significantly lower platelet counts were observed in the sICH group than in the non-sICH group (174,500 vs. 228,000/mm(3), P=0.020). The best cutoff platelet count was 195,000/mm(3), and patients with platelet counts of <195,000/mm(3) had a 5.4-times higher risk of developing sICH than those with platelet counts of >= 195,000/mm(3). Conclusion Platelet count was the only independent parameter associated with sICH among the blood test indexes. Mild thrombocytopenia may increase the risk of sICH after intravenous administration of rtPA. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한응급의학회 | - |
dc.title | Characteristics of blood tests in patients with acute cerebral infarction who developed symptomatic intracranial hemorrhage after intravenous administration of recombinant tissue plasminogen activator | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.15441/ceem.18.056 | - |
dc.identifier.scopusid | 2-s2.0-85069502713 | - |
dc.identifier.wosid | 000473306500009 | - |
dc.identifier.bibliographicCitation | Clinical and Experimental Emergency Medicine, v.6, no.2, pp 160 - 168 | - |
dc.citation.title | Clinical and Experimental Emergency Medicine | - |
dc.citation.volume | 6 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 160 | - |
dc.citation.endPage | 168 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002480377 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | esci | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Emergency Medicine | - |
dc.relation.journalWebOfScienceCategory | Emergency Medicine | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | HEALTH-CARE PROFESSIONALS | - |
dc.subject.keywordPlus | EARLY MANAGEMENT | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | THROMBOLYSIS | - |
dc.subject.keywordPlus | ALTEPLASE | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | ONSET | - |
dc.subject.keywordPlus | ECASS | - |
dc.subject.keywordPlus | PREDICTORS | - |
dc.subject.keywordAuthor | Cerebral infarction | - |
dc.subject.keywordAuthor | Thrombolytic therapy | - |
dc.subject.keywordAuthor | Intracranial hemorrhages | - |
dc.subject.keywordAuthor | Hematologic tests | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.