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Synthesis of Fluoromethyl-Substituted Cyclopentanones via Radical Fluorination and 1,2-Alkyl Migration Cascade of Alkenyl Cyclobutanols

Authors
Kim, YubinKim, Dae Young
Issue Date
May-2019
Publisher
Wiley - VCH Verlag GmbH & Co. KG
Keywords
fluorination; rearrangement; 1,2 migration; radical reactions; ring expansion
Citation
Asian Journal of Organic Chemistry, v.8, no.5, pp 679 - 682
Pages
4
Journal Title
Asian Journal of Organic Chemistry
Volume
8
Number
5
Start Page
679
End Page
682
URI
https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4551
DOI
10.1002/ajoc.201900029
ISSN
2193-5807
2193-5815
Abstract
A radical fluorination/1,2-alkyl migration cascade process of alkenyl cyclobutanols was developed in this study. This approach provides a mild and convenient access to the synthesis of fluoromethyl-substituted cyclopentanone derivatives from the coupling reaction of alkenyl cyclobutanols with Selectfluor as the fluorine radical source.
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