The Effect of Globus Pallidus Interna Deep Brain Stimulation on a Dystonia Patient with the GNAL Mutation Compared to Patients with DYT1 and DYT6
DC Field | Value | Language |
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dc.contributor.author | Ahn, Jong Hyeon | - |
dc.contributor.author | Kim, Ah Reum | - |
dc.contributor.author | Kim, Nayoung K. D. | - |
dc.contributor.author | Park, Woong-Yang | - |
dc.contributor.author | Kim, Ji Sun | - |
dc.contributor.author | Kim, Minkyeong | - |
dc.contributor.author | Park, Jongkyu | - |
dc.contributor.author | Lee, Jung-Il | - |
dc.contributor.author | Cho, Jin Whan | - |
dc.contributor.author | Cho, Kyung Rae | - |
dc.contributor.author | Youn, Jinyoung | - |
dc.date.accessioned | 2021-08-11T09:44:06Z | - |
dc.date.available | 2021-08-11T09:44:06Z | - |
dc.date.issued | 2019-05 | - |
dc.identifier.issn | 2005-940X | - |
dc.identifier.issn | 2093-4939 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4556 | - |
dc.description.abstract | Objective The aim of this study was to investigate the efficacy of globus pallidus interna deep brain stimulation (GPi-DBS) for treating dystonia due to the GNAL mutation. Methods We provide the first report of a dystonia patient with a genetically confirmed GNAL mutation in the Korean population and reviewed the literature on patients with the GNAL mutation who underwent GPi-DBS. We compared the effectiveness of DBS in patients with the GNAL mutation compared to that in patients with DYT1 and DYT6 in a previous study. Results Patients with the GNAL mutation and those with DYT1 had higher early responder rates (GNAT 5/5, 100%; DYT1, 7/7, 100%) than did patients with DYT6 (p = 0.047). The responder rates at late follow-up did not differ statistically among the three groups (p = 0.278). The decrease in the dystonia motor scale score in the GNAL group was 46.9% at early follow-up and 63.4% at late follow-up. Conclusion GPi-DBS would be an effective treatment option for dystonia patients with the GNAL mutation who are resistant to medication or botulinum toxin treatment. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한파킨슨병및이상운동질환학회 | - |
dc.title | The Effect of Globus Pallidus Interna Deep Brain Stimulation on a Dystonia Patient with the GNAL Mutation Compared to Patients with DYT1 and DYT6 | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.14802/jmd.19006 | - |
dc.identifier.wosid | 000469799500007 | - |
dc.identifier.bibliographicCitation | Journal Of Movement Disorders, v.12, no.2, pp 120 - 124 | - |
dc.citation.title | Journal Of Movement Disorders | - |
dc.citation.volume | 12 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 120 | - |
dc.citation.endPage | 124 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002469433 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | esci | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordAuthor | Deep brain stimulation | - |
dc.subject.keywordAuthor | GNAL | - |
dc.subject.keywordAuthor | Dystonia | - |
dc.subject.keywordAuthor | DYT25 | - |
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