Usefulness of synchrotron radiation for three-dimensional microstructure analysis of the mouse tibia

Abstract

This study was to construct a quantitative analysis for the diagnosis and evaluation of osteoporosis by using synchrotron radiation based X-ray, which can analyze the three-dimensional microstructure of white mouse tibia. The anatomical structure and microstructure of the white mouse tibia was obtained through synchrotron radiation, and to achieve this, three-dimensional structural analysis was performed. Then, we visualized the quantified analysis and microstructure information with high-resolution imagery through the image data obtained by synchrotron radiation. In addition, it was confirmed that synchrotron radiation can obtain more reliable results through accurate observation than analysis by the mechanical method. The present invention can provide the diagnosis and evaluation associated with osteoporosis. It is expected that this will provide a basis for the evaluation and prevention of evidence-based skeletal diseases.