Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study
DC Field | Value | Language |
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dc.contributor.author | Qian, Frank | - |
dc.contributor.author | Wang, Shengfeng | - |
dc.contributor.author | Mitchell, Jonathan | - |
dc.contributor.author | McGuffog, Lesley | - |
dc.contributor.author | Barrowdale, Daniel | - |
dc.contributor.author | Leslie, Goska | - |
dc.contributor.author | Oosterwijk, Jan C. | - |
dc.contributor.author | Chung, Wendy K. | - |
dc.contributor.author | Evans, D. Gareth | - |
dc.contributor.author | Engel, Christoph | - |
dc.contributor.author | Kast, Karin | - |
dc.contributor.author | Aalfs, Cora M. | - |
dc.contributor.author | Adank, Muriel A. | - |
dc.contributor.author | Adlard, Julian | - |
dc.contributor.author | Agnarsson, Bjarni A. | - |
dc.contributor.author | Aittomaki, Kristiina | - |
dc.contributor.author | Alducci, Elisa | - |
dc.contributor.author | Andrulis, Irene L. | - |
dc.contributor.author | Arun, Banu K. | - |
dc.contributor.author | Ausems, Margreet G. E. M. | - |
dc.contributor.author | Azzollini, Jacopo | - |
dc.contributor.author | Barouk-Simonet, Emmanuelle | - |
dc.contributor.author | Barwell, Julian | - |
dc.contributor.author | Belotti, Muriel | - |
dc.contributor.author | Benitez, Javier | - |
dc.contributor.author | Berger, Andreas | - |
dc.contributor.author | Borg, Ake | - |
dc.contributor.author | Bradbury, Angela R. | - |
dc.contributor.author | Brunet, Joan | - |
dc.contributor.author | Buys, Saundra S. | - |
dc.contributor.author | Caldes, Trinidad | - |
dc.contributor.author | Caligo, Maria A. | - |
dc.contributor.author | Campbell, Ian | - |
dc.contributor.author | Caputo, Sandrine M. | - |
dc.contributor.author | Chiquette, Jocelyne | - |
dc.contributor.author | Claes, Kathleen B. M. | - |
dc.contributor.author | Collee, J. Margriet | - |
dc.contributor.author | Couch, Fergus J. | - |
dc.contributor.author | Coupier, Isabelle | - |
dc.contributor.author | Daly, Mary B. | - |
dc.contributor.author | Davidson, Rosemarie | - |
dc.contributor.author | Diez, Orland | - |
dc.contributor.author | Domchek, Susan M. | - |
dc.contributor.author | Donaldson, Alan | - |
dc.contributor.author | Dorfling, Cecilia M. | - |
dc.contributor.author | Eeles, Ros | - |
dc.contributor.author | Feliubadalo, Lidia | - |
dc.contributor.author | Foretova, Lenka | - |
dc.contributor.author | Fowler, Jeffrey | - |
dc.contributor.author | Friedman, Eitan | - |
dc.contributor.author | Frost, Debra | - |
dc.contributor.author | Ganz, Patricia A. | - |
dc.contributor.author | Garber, Judy | - |
dc.contributor.author | Garcia-Barberan, Vanesa | - |
dc.contributor.author | Glendon, Gord | - |
dc.contributor.author | Godwin, Andrew K. | - |
dc.contributor.author | Gomez Garcia, Encarna B. | - |
dc.contributor.author | Gronwald, Jacek | - |
dc.contributor.author | Hahnen, Eric | - |
dc.contributor.author | Hamann, Ute | - |
dc.contributor.author | Henderson, Alex | - |
dc.contributor.author | Hendricks, Carolyn B. | - |
dc.contributor.author | Hopper, John L. | - |
dc.contributor.author | Hulick, Peter J. | - |
dc.contributor.author | Imyanitov, Evgeny N. | - |
dc.contributor.author | Isaacs, Claudine | - |
dc.contributor.author | Izatt, Louise | - |
dc.contributor.author | Izquierdo, Angel | - |
dc.contributor.author | Jakubowska, Anna | - |
dc.contributor.author | Kaczmarek, Katarzyna | - |
dc.contributor.author | Kang, Eunyoung | - |
dc.contributor.author | Karlan, Beth Y. | - |
dc.contributor.author | Kets, Carolien M. | - |
dc.contributor.author | Kim, Sung-Won | - |
dc.contributor.author | Kim, Zisun | - |
dc.contributor.author | Kwong, Ava | - |
dc.contributor.author | Laitman, Yael | - |
dc.contributor.author | Lasset, Christine | - |
dc.contributor.author | Lee, Min Hyuk | - |
dc.contributor.author | Lee, Jong Won | - |
dc.contributor.author | Lee, Jihyoun | - |
dc.contributor.author | Lester, Jenny | - |
dc.contributor.author | Lesueur, Fabienne | - |
dc.contributor.author | Loud, Jennifer T. | - |
dc.contributor.author | Lubinski, Jan | - |
dc.contributor.author | Mebirouk, Noura | - |
dc.contributor.author | Meijers-Heijboer, Hanne E. J. | - |
dc.contributor.author | Meindl, Alfons | - |
dc.contributor.author | Miller, Austin | - |
dc.contributor.author | Montagna, Marco | - |
dc.contributor.author | Mooij, Thea M. | - |
dc.contributor.author | Morrison, Patrick J. | - |
dc.contributor.author | Mouret-Fourme, Emmanuelle | - |
dc.contributor.author | Nathanson, Katherine L. | - |
dc.contributor.author | Neuhausen, Susan L. | - |
dc.contributor.author | Nevanlinna, Heli | - |
dc.contributor.author | Niederacher, Dieter | - |
dc.contributor.author | Nielsen, Finn C. | - |
dc.contributor.author | Nussbaum, Robert L. | - |
dc.contributor.author | Offit, Kenneth | - |
dc.contributor.author | Olah, Edith | - |
dc.contributor.author | Ong, Kai-Ren | - |
dc.contributor.author | Ottini, Laura | - |
dc.contributor.author | Park, Sue K. | - |
dc.contributor.author | Peterlongo, Paolo | - |
dc.contributor.author | Pfeiler, Georg | - |
dc.contributor.author | Phelan, Catherine M. | - |
dc.contributor.author | Poppe, Bruce | - |
dc.contributor.author | Pradhan, Nisha | - |
dc.contributor.author | Radice, Paolo | - |
dc.contributor.author | Ramus, Susan J. | - |
dc.contributor.author | Rantala, Johanna | - |
dc.contributor.author | Robson, Mark | - |
dc.contributor.author | Rodriguez, Gustavo C. | - |
dc.contributor.author | Schmutzler, Rita K. | - |
dc.contributor.author | Selkirk, Christina G. Hutten | - |
dc.contributor.author | Shah, Payal D. | - |
dc.contributor.author | Simard, Jacques | - |
dc.contributor.author | Singer, Christian F. | - |
dc.contributor.author | Sokolowska, Johanna | - |
dc.contributor.author | Stoppa-Lyonnet, Dominique | - |
dc.contributor.author | Sutter, Christian | - |
dc.contributor.author | Tan, Yen Yen | - |
dc.contributor.author | Teixeira, Manuel R. | - |
dc.contributor.author | Teo, Soo H. | - |
dc.contributor.author | Terry, Mary Beth | - |
dc.contributor.author | Thomassen, Mads | - |
dc.contributor.author | Tischkowitz, Marc | - |
dc.contributor.author | Toland, Amanda E. | - |
dc.contributor.author | Tucker, Katherine M. | - |
dc.contributor.author | Tung, Nadine | - |
dc.contributor.author | van Asperen, Christi J. | - |
dc.contributor.author | van Engelen, Klaartje | - |
dc.contributor.author | van Rensburg, Elizabeth J. | - |
dc.contributor.author | Wang-Gohrke, Shan | - |
dc.contributor.author | Wappenschmidt, Barbara | - |
dc.contributor.author | Weitzel, Jeffrey N. | - |
dc.contributor.author | Yannoukakos, Drakoulis | - |
dc.contributor.author | Greene, Mark H. | - |
dc.contributor.author | Rookus, Matti A. | - |
dc.contributor.author | Easton, Douglas F. | - |
dc.contributor.author | Chenevix-Trench, Georgia | - |
dc.contributor.author | Antoniou, Antonis C. | - |
dc.contributor.author | Goldgar, David E. | - |
dc.contributor.author | Olopade, Olufunmilayo I. | - |
dc.contributor.author | Rebbeck, Timothy R. | - |
dc.contributor.author | Huo, Dezheng | - |
dc.date.accessioned | 2021-08-11T09:44:13Z | - |
dc.date.available | 2021-08-11T09:44:13Z | - |
dc.date.issued | 2019-04 | - |
dc.identifier.issn | 0027-8874 | - |
dc.identifier.issn | 1460-2105 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4591 | - |
dc.description.abstract | Background: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear. Methods: We used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer. We created a height genetic score using 586 height-associated variants and a BMI genetic score using 93 BMI-associated variants. We examined both observed and genetically determined height and BMI with breast cancer risk using weighted Cox models. All statistical tests were two-sided. Results: Observed height was positively associated with breast cancer risk (HR = 1.09 per 10 cm increase, 95% confidence interval [CI] = 1.0 to 1.17; P = 1.17). Height genetic score was positively associated with breast cancer, although this was not statistically significant (per 10 cm increase in genetically predicted height, HR = 1.04, 95% CI = 0.93 to 1.17; P = .47). Observed BMI was inversely associated with breast cancer risk (per 5 kg/m(2) increase, HR = 0.94, 95% CI = 0.90 to 0.98; P = .007). BMI genetic score was also inversely associated with breast cancer risk (per 5 kg/m2 increase in genetically predicted BMI, HR = 0.87, 95% CI = 0.76 to 0.98; P = .02). BMI was primarily associated with premenopausal breast cancer. Conclusion: Height is associated with overall breast cancer and BMI is associated with premenopausal breast cancer in BRCA1/2 mutation carriers. Incorporating height and BMI, particularly genetic score, into risk assessment may improve cancer management. | - |
dc.format.extent | 15 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Oxford University Press | - |
dc.title | Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1093/jnci/djy132 | - |
dc.identifier.scopusid | 2-s2.0-85064286333 | - |
dc.identifier.wosid | 000488504400003 | - |
dc.identifier.bibliographicCitation | Journal of the National Cancer Institute, v.111, no.4, pp 350 - 364 | - |
dc.citation.title | Journal of the National Cancer Institute | - |
dc.citation.volume | 111 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 350 | - |
dc.citation.endPage | 364 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | BIOLOGICAL PATHWAYS | - |
dc.subject.keywordPlus | GENETIC-VARIANTS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | LOCI | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | WEIGHT | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordAuthor | breast cancer | - |
dc.subject.keywordAuthor | BRCA1/2 mutation carriers | - |
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