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Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study

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dc.contributor.authorQian, Frank-
dc.contributor.authorWang, Shengfeng-
dc.contributor.authorMitchell, Jonathan-
dc.contributor.authorMcGuffog, Lesley-
dc.contributor.authorBarrowdale, Daniel-
dc.contributor.authorLeslie, Goska-
dc.contributor.authorOosterwijk, Jan C.-
dc.contributor.authorChung, Wendy K.-
dc.contributor.authorEvans, D. Gareth-
dc.contributor.authorEngel, Christoph-
dc.contributor.authorKast, Karin-
dc.contributor.authorAalfs, Cora M.-
dc.contributor.authorAdank, Muriel A.-
dc.contributor.authorAdlard, Julian-
dc.contributor.authorAgnarsson, Bjarni A.-
dc.contributor.authorAittomaki, Kristiina-
dc.contributor.authorAlducci, Elisa-
dc.contributor.authorAndrulis, Irene L.-
dc.contributor.authorArun, Banu K.-
dc.contributor.authorAusems, Margreet G. E. M.-
dc.contributor.authorAzzollini, Jacopo-
dc.contributor.authorBarouk-Simonet, Emmanuelle-
dc.contributor.authorBarwell, Julian-
dc.contributor.authorBelotti, Muriel-
dc.contributor.authorBenitez, Javier-
dc.contributor.authorBerger, Andreas-
dc.contributor.authorBorg, Ake-
dc.contributor.authorBradbury, Angela R.-
dc.contributor.authorBrunet, Joan-
dc.contributor.authorBuys, Saundra S.-
dc.contributor.authorCaldes, Trinidad-
dc.contributor.authorCaligo, Maria A.-
dc.contributor.authorCampbell, Ian-
dc.contributor.authorCaputo, Sandrine M.-
dc.contributor.authorChiquette, Jocelyne-
dc.contributor.authorClaes, Kathleen B. M.-
dc.contributor.authorCollee, J. Margriet-
dc.contributor.authorCouch, Fergus J.-
dc.contributor.authorCoupier, Isabelle-
dc.contributor.authorDaly, Mary B.-
dc.contributor.authorDavidson, Rosemarie-
dc.contributor.authorDiez, Orland-
dc.contributor.authorDomchek, Susan M.-
dc.contributor.authorDonaldson, Alan-
dc.contributor.authorDorfling, Cecilia M.-
dc.contributor.authorEeles, Ros-
dc.contributor.authorFeliubadalo, Lidia-
dc.contributor.authorForetova, Lenka-
dc.contributor.authorFowler, Jeffrey-
dc.contributor.authorFriedman, Eitan-
dc.contributor.authorFrost, Debra-
dc.contributor.authorGanz, Patricia A.-
dc.contributor.authorGarber, Judy-
dc.contributor.authorGarcia-Barberan, Vanesa-
dc.contributor.authorGlendon, Gord-
dc.contributor.authorGodwin, Andrew K.-
dc.contributor.authorGomez Garcia, Encarna B.-
dc.contributor.authorGronwald, Jacek-
dc.contributor.authorHahnen, Eric-
dc.contributor.authorHamann, Ute-
dc.contributor.authorHenderson, Alex-
dc.contributor.authorHendricks, Carolyn B.-
dc.contributor.authorHopper, John L.-
dc.contributor.authorHulick, Peter J.-
dc.contributor.authorImyanitov, Evgeny N.-
dc.contributor.authorIsaacs, Claudine-
dc.contributor.authorIzatt, Louise-
dc.contributor.authorIzquierdo, Angel-
dc.contributor.authorJakubowska, Anna-
dc.contributor.authorKaczmarek, Katarzyna-
dc.contributor.authorKang, Eunyoung-
dc.contributor.authorKarlan, Beth Y.-
dc.contributor.authorKets, Carolien M.-
dc.contributor.authorKim, Sung-Won-
dc.contributor.authorKim, Zisun-
dc.contributor.authorKwong, Ava-
dc.contributor.authorLaitman, Yael-
dc.contributor.authorLasset, Christine-
dc.contributor.authorLee, Min Hyuk-
dc.contributor.authorLee, Jong Won-
dc.contributor.authorLee, Jihyoun-
dc.contributor.authorLester, Jenny-
dc.contributor.authorLesueur, Fabienne-
dc.contributor.authorLoud, Jennifer T.-
dc.contributor.authorLubinski, Jan-
dc.contributor.authorMebirouk, Noura-
dc.contributor.authorMeijers-Heijboer, Hanne E. J.-
dc.contributor.authorMeindl, Alfons-
dc.contributor.authorMiller, Austin-
dc.contributor.authorMontagna, Marco-
dc.contributor.authorMooij, Thea M.-
dc.contributor.authorMorrison, Patrick J.-
dc.contributor.authorMouret-Fourme, Emmanuelle-
dc.contributor.authorNathanson, Katherine L.-
dc.contributor.authorNeuhausen, Susan L.-
dc.contributor.authorNevanlinna, Heli-
dc.contributor.authorNiederacher, Dieter-
dc.contributor.authorNielsen, Finn C.-
dc.contributor.authorNussbaum, Robert L.-
dc.contributor.authorOffit, Kenneth-
dc.contributor.authorOlah, Edith-
dc.contributor.authorOng, Kai-Ren-
dc.contributor.authorOttini, Laura-
dc.contributor.authorPark, Sue K.-
dc.contributor.authorPeterlongo, Paolo-
dc.contributor.authorPfeiler, Georg-
dc.contributor.authorPhelan, Catherine M.-
dc.contributor.authorPoppe, Bruce-
dc.contributor.authorPradhan, Nisha-
dc.contributor.authorRadice, Paolo-
dc.contributor.authorRamus, Susan J.-
dc.contributor.authorRantala, Johanna-
dc.contributor.authorRobson, Mark-
dc.contributor.authorRodriguez, Gustavo C.-
dc.contributor.authorSchmutzler, Rita K.-
dc.contributor.authorSelkirk, Christina G. Hutten-
dc.contributor.authorShah, Payal D.-
dc.contributor.authorSimard, Jacques-
dc.contributor.authorSinger, Christian F.-
dc.contributor.authorSokolowska, Johanna-
dc.contributor.authorStoppa-Lyonnet, Dominique-
dc.contributor.authorSutter, Christian-
dc.contributor.authorTan, Yen Yen-
dc.contributor.authorTeixeira, Manuel R.-
dc.contributor.authorTeo, Soo H.-
dc.contributor.authorTerry, Mary Beth-
dc.contributor.authorThomassen, Mads-
dc.contributor.authorTischkowitz, Marc-
dc.contributor.authorToland, Amanda E.-
dc.contributor.authorTucker, Katherine M.-
dc.contributor.authorTung, Nadine-
dc.contributor.authorvan Asperen, Christi J.-
dc.contributor.authorvan Engelen, Klaartje-
dc.contributor.authorvan Rensburg, Elizabeth J.-
dc.contributor.authorWang-Gohrke, Shan-
dc.contributor.authorWappenschmidt, Barbara-
dc.contributor.authorWeitzel, Jeffrey N.-
dc.contributor.authorYannoukakos, Drakoulis-
dc.contributor.authorGreene, Mark H.-
dc.contributor.authorRookus, Matti A.-
dc.contributor.authorEaston, Douglas F.-
dc.contributor.authorChenevix-Trench, Georgia-
dc.contributor.authorAntoniou, Antonis C.-
dc.contributor.authorGoldgar, David E.-
dc.contributor.authorOlopade, Olufunmilayo I.-
dc.contributor.authorRebbeck, Timothy R.-
dc.contributor.authorHuo, Dezheng-
dc.date.accessioned2021-08-11T09:44:13Z-
dc.date.available2021-08-11T09:44:13Z-
dc.date.issued2019-04-
dc.identifier.issn0027-8874-
dc.identifier.issn1460-2105-
dc.identifier.urihttps://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4591-
dc.description.abstractBackground: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear. Methods: We used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer. We created a height genetic score using 586 height-associated variants and a BMI genetic score using 93 BMI-associated variants. We examined both observed and genetically determined height and BMI with breast cancer risk using weighted Cox models. All statistical tests were two-sided. Results: Observed height was positively associated with breast cancer risk (HR = 1.09 per 10 cm increase, 95% confidence interval [CI] = 1.0 to 1.17; P = 1.17). Height genetic score was positively associated with breast cancer, although this was not statistically significant (per 10 cm increase in genetically predicted height, HR = 1.04, 95% CI = 0.93 to 1.17; P = .47). Observed BMI was inversely associated with breast cancer risk (per 5 kg/m(2) increase, HR = 0.94, 95% CI = 0.90 to 0.98; P = .007). BMI genetic score was also inversely associated with breast cancer risk (per 5 kg/m2 increase in genetically predicted BMI, HR = 0.87, 95% CI = 0.76 to 0.98; P = .02). BMI was primarily associated with premenopausal breast cancer. Conclusion: Height is associated with overall breast cancer and BMI is associated with premenopausal breast cancer in BRCA1/2 mutation carriers. Incorporating height and BMI, particularly genetic score, into risk assessment may improve cancer management.-
dc.format.extent15-
dc.language영어-
dc.language.isoENG-
dc.publisherOxford University Press-
dc.titleHeight and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1093/jnci/djy132-
dc.identifier.scopusid2-s2.0-85064286333-
dc.identifier.wosid000488504400003-
dc.identifier.bibliographicCitationJournal of the National Cancer Institute, v.111, no.4, pp 350 - 364-
dc.citation.titleJournal of the National Cancer Institute-
dc.citation.volume111-
dc.citation.number4-
dc.citation.startPage350-
dc.citation.endPage364-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaOncology-
dc.relation.journalWebOfScienceCategoryOncology-
dc.subject.keywordPlusBIOLOGICAL PATHWAYS-
dc.subject.keywordPlusGENETIC-VARIANTS-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusLOCI-
dc.subject.keywordPlusIDENTIFICATION-
dc.subject.keywordPlusEPIDEMIOLOGY-
dc.subject.keywordPlusINSULIN-
dc.subject.keywordPlusOBESITY-
dc.subject.keywordPlusWEIGHT-
dc.subject.keywordPlusFAMILY-
dc.subject.keywordAuthorbreast cancer-
dc.subject.keywordAuthorBRCA1/2 mutation carriers-
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