Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes
DC Field | Value | Language |
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dc.contributor.author | Bae, Jung Hwan | - |
dc.contributor.author | Jo, Seung, II | - |
dc.contributor.author | Kim, Seong Jin | - |
dc.contributor.author | Lee, Jong Min | - |
dc.contributor.author | Jeong, Ji Hun | - |
dc.contributor.author | Kang, Jeong Suk | - |
dc.contributor.author | Cho, Nam-Jun | - |
dc.contributor.author | Kim, Sang Soo | - |
dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Moon, Jong-Seok | - |
dc.date.accessioned | 2021-08-11T09:44:15Z | - |
dc.date.available | 2021-08-11T09:44:15Z | - |
dc.date.issued | 2019-04 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4593 | - |
dc.description.abstract | Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance and type 2 diabetes. Damaged mitochondria DNA (mtDNA) may have a role in regulating hyperglycemia during type 2 diabetes. Circulating cell-free mitochondria DNA (ccf-mtDNA) was found in serum and plasma from patients and has been linked to the prognosis factors in various human diseases. However, the role of ccf-mtDNA in chronic inflammation in type 2 diabetes is unclear. In this study, we hypothesized that the ccf-mtDNA levels are associated with chronic inflammation in patients with type 2 diabetes. The mtDNA levels were elevated in the plasma from patients with type 2 diabetes compared to healthy subjects. The elevated mtDNA levels were associated with interleukin-1 (IL-1) levels in patients with type 2 diabetes. The mtDNA, from patients with type 2 diabetes, induced absent in melanoma 2 (AIM2) inflammasome-dependent caspase-1 activation and IL-1 and IL-18 secretion in macrophages. Our results suggest that the ccf-mtDNA might contribute to AIM2 inflammasome-mediated chronic inflammation in type 2 diabetes. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/cells8040328 | - |
dc.identifier.wosid | 000467304300042 | - |
dc.identifier.bibliographicCitation | Cells, v.8, no.4 | - |
dc.citation.title | Cells | - |
dc.citation.volume | 8 | - |
dc.citation.number | 4 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | FREE MITOCHONDRIAL-DNA | - |
dc.subject.keywordPlus | PLASMA NUCLEAR | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | BIOMARKER | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | NEPHROPATHY | - |
dc.subject.keywordPlus | DYSFUNCTION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordAuthor | ccf-mtDNA | - |
dc.subject.keywordAuthor | chronic inflammation | - |
dc.subject.keywordAuthor | AIM2 inflammasome | - |
dc.subject.keywordAuthor | type 2 diabetes | - |
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