TmToll-7 Plays a Crucial Role in Innate Immune Responses Against Gram-Negative Bacteria by Regulating 5 AMP Genes in Tenebrio molitor
DC Field | Value | Language |
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dc.contributor.author | Park, Soyi | - |
dc.contributor.author | Jo, Yong Hun | - |
dc.contributor.author | Park, Ki Beom | - |
dc.contributor.author | Ko, Hye Jin | - |
dc.contributor.author | Kim, Chang Eun | - |
dc.contributor.author | Bae, Young Min | - |
dc.contributor.author | Kim, Bobae | - |
dc.contributor.author | Jun, Sung Ah | - |
dc.contributor.author | Bang, In Seok | - |
dc.contributor.author | Lee, Yong Seok | - |
dc.contributor.author | Kim, Yu Jung | - |
dc.contributor.author | Han, Yeon Soo | - |
dc.date.accessioned | 2021-08-11T10:23:27Z | - |
dc.date.available | 2021-08-11T10:23:27Z | - |
dc.date.issued | 2019-03-12 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4653 | - |
dc.description.abstract | Although it is known that the Drosophila Toll-7 receptor plays a critical role in antiviral autophagy, its function in other insects has not yet been reported. Here, we have identified a Toll-like receptor 7 gene, TmToll-7, in the coleopteran insect T molitor and examined its potential role in antibacterial and antifungal immunity. We showed that TmToll-7 expression was significantly induced in larvae 6 h after infection with Escherichia coli and Staphylococcus aureus and 6 h after infection with Candida albicans. However, even though TmToll-7 was induced by all three pathogens, we found that TmToll-7 knockdown significantly reduced larval survival to E. coli, but not to S. aureus, and C. albicans infections. To understand the reasons for this difference, we examined the effects of TmToll-7 knockdown on antimicrobial peptide (AMP) gene expression and found a significant reduction of E. coli-induced expression of AMP genes such as TmTenecin-1, TmDefensin-1, TmDefensin-2, TmColeoptericin-1 , and TmAttacin-2. Furthermore, TmToll-7 knockdown larvae infected with E. coli showed significantly higher bacterial growth in the hemolymph compared to control larvae treated with Vermilion dsRNA. Taken together, our results suggest that TmToll-7 plays an important role in regulating the immune response of T molitor to E coli. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | TmToll-7 Plays a Crucial Role in Innate Immune Responses Against Gram-Negative Bacteria by Regulating 5 AMP Genes in Tenebrio molitor | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3389/fimmu.2019.00310 | - |
dc.identifier.scopusid | 2-s2.0-85064015273 | - |
dc.identifier.wosid | 000461082800001 | - |
dc.identifier.bibliographicCitation | Frontiers in Immunology, v.10 | - |
dc.citation.title | Frontiers in Immunology | - |
dc.citation.volume | 10 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTORS | - |
dc.subject.keywordPlus | DROSOPHILA-MELANOGASTER | - |
dc.subject.keywordPlus | PATHOGEN RECOGNITION | - |
dc.subject.keywordPlus | PROTEOLYTIC CASCADE | - |
dc.subject.keywordPlus | CYTOKINE SPATZLE | - |
dc.subject.keywordPlus | HOST-DEFENSE | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | INTERPROSCAN | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordAuthor | Toll-7 | - |
dc.subject.keywordAuthor | Tenebrio molitor | - |
dc.subject.keywordAuthor | microbial infection | - |
dc.subject.keywordAuthor | RNAi | - |
dc.subject.keywordAuthor | antimicrobial peptides | - |
dc.subject.keywordAuthor | AMP assay | - |
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