Clinical and endoscopic characteristics of sessile serrated adenomas/polyps with dysplasia/adenocarcinoma in a Korean population: A Korean Association for the Study of Intestinal Diseases (KASID) multicenter study
DC Field | Value | Language |
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dc.contributor.author | Kim, Ki-Hyun | - |
dc.contributor.author | Kim, Kyeong-Ok | - |
dc.contributor.author | Jung, Yunho | - |
dc.contributor.author | Lee, Jun | - |
dc.contributor.author | Kim, Sang-Wook | - |
dc.contributor.author | Kim, Jae-Hyun | - |
dc.contributor.author | Kim, Tae-Jun | - |
dc.contributor.author | Cho, Young-Seok | - |
dc.contributor.author | Joo, Young-Eun | - |
dc.date.accessioned | 2021-08-11T10:23:28Z | - |
dc.date.available | 2021-08-11T10:23:28Z | - |
dc.date.issued | 2019-03-08 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4655 | - |
dc.description.abstract | Sessile serrated adenomas/polyps (SSA/Ps) are precancerous lesions that account for one-third of colorectal cancers. The endoscopic and pathologic differentiation between SSA/Ps without dysplasia (SSA/POs) and SSA/Ps with dysplasia or adenocarcinoma (SSA/PDAs) can be difficult. This study aimed to assess the clinical characteristics of SSA/PDs. This multicenter retrospective cohort study included 532 patients who underwent endoscopic resection and were pathologically diagnosed with SSA/POs and SSA/PDAs. Initially, medical, endoscopic, and histopathological records of patients who underwent endoscopic resection of SSA/POs and SSA/PDAs at eight university hospitals in Korea between January 2005 and December 2015 were reviewed. A total of 307 (57.7%) patients were detected in men and 319 (60.0%) were located in the proximal colon. Most SSA/Ps had a flat, slightly elevated, or sessile morphology. The most prevalent endoscopic findings of SSA/Ps were nodular surface (244, 45.9%), disrupted vascular pattern (232, 43.6%), altered fold contour (141, 26.5%), dome-shaped morphology (135, 25.4%), and pale color (115, 21.6%). SSA/POs were more commonly found in the proximal colon, compared to SSA/PDAs. SSA/PDAs displayed 0-Ip, Isp, IIb or IIa + IIc morphologies more frequently, while SSA/POs displayed 0-Is or IIa morphology more frequently. The frequency of a rim of debris/bubbles was significantly higher in SSA/POs, while nodular surface and disrupted vascular pattern were significantly higher in SSA/PDAs. In the univariate analysis of endoscopic features, SSA/PDAs were significantly associated with the distal colon location, 0-Isp and IIb morphologies, nodular surface, and disrupted vascular pattern. In the multivariate analysis, 0-IIb, nodular surface, and disrupted vascular pattern were significantly associated with SSA/PDAs. SSA/Ps with 0-IIb morphology, nodular surface and disrupted vascular pattern are associated with an increased risk of dysplasia or adenocarcinoma. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Clinical and endoscopic characteristics of sessile serrated adenomas/polyps with dysplasia/adenocarcinoma in a Korean population: A Korean Association for the Study of Intestinal Diseases (KASID) multicenter study | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1038/s41598-019-40559-w | - |
dc.identifier.scopusid | 2-s2.0-85062603904 | - |
dc.identifier.wosid | 000460627700034 | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.9 | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | SYNCHRONOUS ADVANCED NEOPLASIA | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | MUCOSAL RESECTION | - |
dc.subject.keywordPlus | SUBMUCOSAL DISSECTION | - |
dc.subject.keywordPlus | POLYPS | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | ADENOMA/POLYP | - |
dc.subject.keywordPlus | DYSPLASIA | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordAuthor | Sessile serrated adenomas/polyps | - |
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