In-depth study of lin-28 suggests selectively conserved let-7 independent mechanism in Drosophila
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Mihye | - |
dc.contributor.author | Thanh My Thi Nguyen | - |
dc.contributor.author | Kim, Kiyoung | - |
dc.date.accessioned | 2021-08-11T10:23:29Z | - |
dc.date.available | 2021-08-11T10:23:29Z | - |
dc.date.issued | 2019-03-01 | - |
dc.identifier.issn | 0378-1119 | - |
dc.identifier.issn | 1879-0038 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4664 | - |
dc.description.abstract | Lin-28 is a conserved RNA-binding protein that is involved in a wide range of developmental processes and pathogenesis. At the molecular level, Lin-28 blocks the maturation of let-7 and regulates translation of certain mRNA targets. In Drosophila, Lin-28 is reported to play a role in oogenesis, muscle formation, and the symmetric division of adult intestinal stem cells. In this study, we characterized Drosophila Lin-28 through a detailed examination of its temporal and spatial expression. Lin-28 is specifically expressed in embryonic nervous and cardiac systems. However, loss or gain of lin-28 function does not cause any abnormality during embryonic development. Instead, the ubiquitous overexpression of Lin-28 leads to lethality from late larval stage to pupal stage, and eye-specific overexpression causes severe cell loss. The ectopic expression of human Lin28A has the same effect as Drosophila Lin-28, indicating functional conservation in Lin-28 orthologs. We also examined the effect of Lin-28 on let-7 biogenesis through the mutant and overexpression analysis. Lin-28 does not block the production of let-7 in Drosophila, which suggests the let-7 independent pathway as a molecular mechanism of Lin-28. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | In-depth study of lin-28 suggests selectively conserved let-7 independent mechanism in Drosophila | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.gene.2018.11.017 | - |
dc.identifier.scopusid | 2-s2.0-85056641862 | - |
dc.identifier.wosid | 000456753500010 | - |
dc.identifier.bibliographicCitation | Gene, v.687, pp 64 - 72 | - |
dc.citation.title | Gene | - |
dc.citation.volume | 687 | - |
dc.citation.startPage | 64 | - |
dc.citation.endPage | 72 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | RNA-BINDING PROTEINS | - |
dc.subject.keywordPlus | LIN28 PROTEINS | - |
dc.subject.keywordPlus | MESSENGER-RNAS | - |
dc.subject.keywordPlus | MICRORNA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordPlus | TRANSLATION | - |
dc.subject.keywordPlus | REGULATOR | - |
dc.subject.keywordPlus | PANNIER | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | Lin-28 | - |
dc.subject.keywordAuthor | let-7 | - |
dc.subject.keywordAuthor | RNA binding protein | - |
dc.subject.keywordAuthor | Embryonic development | - |
dc.subject.keywordAuthor | Drosophila | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.