Bromophenol (5-bromo-3,4-dihydroxybenzaldehyde) isolated from red alga Polysiphonia morrowii inhibits adipogenesis by regulating expression of adipogenic transcription factors and AMP-activated protein kinase activation in 3T3-L1 adipocytes
- Authors
- Ko, Seok-Chun; Ding, Yuling; Kim, Junseong; Ye, Bo-Ram; Kim, Eun-A; Jung, Won-Kyo; Heo, Soo-Jin; Lee, Seung-Hong
- Issue Date
- Mar-2019
- Publisher
- John Wiley & Sons Inc.
- Keywords
- 5-bromo-3,4-dihydroxybenzaldehyde (BD); adipogenesis; AMPK
- Citation
- Phytotherapy Research, v.33, no.3, pp 737 - 744
- Pages
- 8
- Journal Title
- Phytotherapy Research
- Volume
- 33
- Number
- 3
- Start Page
- 737
- End Page
- 744
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4688
- DOI
- 10.1002/ptr.6266
- ISSN
- 0951-418X
1099-1573
- Abstract
- The aim of the present study was to investigate the effect of 5-bromo-3,4-dihydroxybenzaldehyde (BD) isolated from Polysiphonia morrowii on adipogenesis and differentiation of 3T3-L1 preadipocytes into mature adipocytes and its possible mechanism of action. Levels of lipid accumulation and triglyceride were significantly lower in BD treated cells than those in untreated cells. In addition, BD treatment reduced protein expression levels of peroxisome proliferator-activated receptor-gamma, CCAAT/enhancer-binding proteins alpha, and sterol regulatory element-binding protein 1 compared with control (no treatment). It also reduced expression levels of adiponectin, leptin, fatty acid synthase, and fatty acid binding protein 4. AMP-activated protein kinase activation was found to be one specific mechanism involved in the effect of BD. These results demonstrate that BD possesses inhibitory effect on adipogenesis through activating AMP-activated protein kinase signal pathway.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medical Sciences > Department of Pharmaceutical Engineering > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.