Safety and Efficacy of Low-Volume Preparation in the Elderly: Oral Sulfate Solution on the Day before and Split-Dose Regimens (SEE SAFE) Study
DC Field | Value | Language |
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dc.contributor.author | Kwak, Min Seob | - |
dc.contributor.author | Cha, Jae Myung | - |
dc.contributor.author | Yang, Hyo-Joon | - |
dc.contributor.author | Park, Dong Il | - |
dc.contributor.author | Kim, Kyeong Ok | - |
dc.contributor.author | Lee, Jun | - |
dc.contributor.author | Shin, Jeong Eun | - |
dc.contributor.author | Joo, Young-Eun | - |
dc.contributor.author | Park, Jongha | - |
dc.contributor.author | Byeon, Jeong-Sik | - |
dc.contributor.author | Kim, Hyun Gun | - |
dc.date.accessioned | 2021-08-11T10:23:35Z | - |
dc.date.available | 2021-08-11T10:23:35Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.issn | 2005-1212 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4694 | - |
dc.description.abstract | Background/Aims: The use of a low-volume bowel cleansing agent is associated with a greater willingness to undergo repeat colonoscopy. Oral sulfate solution (OSS) is a recently approved low-volume agent; however, its efficacy and safety in the elderly population remain unclear. We aimed to evaluate the efficacy, safety, and acceptability of the OSS preparation, in comparison to those of a standard polyethylene glycol (PEG; 4 L) preparation, in elderly patients. Methods: A multicenter, randomized, investigator-blinded study was conducted. Participants were randomized to receive OSS or 4-L PEG with a split-dose regimen. Bowel cleansing efficacy was assessed using the Boston Bowel Preparation Scale (BBPS). Acceptance, satisfaction, and preparation-related symptoms were recorded. Additionally, blood parameters were analyzed for electrolyte abnormalities and nephrotoxicity. Results: A total of 193 patients were analyzed. No group differences in overall bowel cleansing efficacy were observed, with "adequate" preparations achieved in 95.9% (93/97) and 94.8% (91/96) of patients in the OSS and 4L PEG groups, respectively (p=0.747). However, mean BBPS scores for the entire (p=0.010) and right colon (p=0.001) were significantly higher in the OSS group than in the 4-L PEG group. The severity of clinical adverse events and frequency of acute kidney injury were similarly low, and no clinically meaningful electrolyte changes were identified. Self-reported scores regarding amount (p<0.001) and feeling (p=0.007), as well as overall satisfaction (p=0.001) and willingness to repeat the preparation (92.8% vs 67.7%, p<0.001), were significantly better in the OSS group than in the 4-L PEG group. Conclusions: In elderly individuals, OSS with a split-dose regimen has greater acceptability and comparable efficacy in bowel cleansing compared to 4-L PEG. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 거트앤리버 발행위원회 | - |
dc.title | Safety and Efficacy of Low-Volume Preparation in the Elderly: Oral Sulfate Solution on the Day before and Split-Dose Regimens (SEE SAFE) Study | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5009/gnl18214 | - |
dc.identifier.scopusid | 2-s2.0-85063347367 | - |
dc.identifier.wosid | 000461020800009 | - |
dc.identifier.bibliographicCitation | Gut and Liver, v.13, no.2, pp 176 - 182 | - |
dc.citation.title | Gut and Liver | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 176 | - |
dc.citation.endPage | 182 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002447051 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | BOWEL PREPARATION | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | DIAGNOSTIC YIELD | - |
dc.subject.keywordPlus | REDUCED-VOLUME | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | DUAL-ACTION | - |
dc.subject.keywordPlus | COLONOSCOPY | - |
dc.subject.keywordPlus | OLDER | - |
dc.subject.keywordPlus | PHOSPHATE | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordAuthor | Colonoscopy | - |
dc.subject.keywordAuthor | Cathartics | - |
dc.subject.keywordAuthor | Safety | - |
dc.subject.keywordAuthor | Treatment outcome | - |
dc.subject.keywordAuthor | Aged | - |
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