Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Fox, Benjamin M. | - |
dc.contributor.author | Gil, Hyo-Wook | - |
dc.contributor.author | Kirkbride-Romeo, Lara | - |
dc.contributor.author | Bagchi, Rushita A. | - |
dc.contributor.author | Wennersten, Sara A. | - |
dc.contributor.author | Haefner, Korey R. | - |
dc.contributor.author | Skrypnyk, Nataliya I. | - |
dc.contributor.author | Brown, Carolyn N. | - |
dc.contributor.author | Soranno, Danielle E. | - |
dc.contributor.author | Gist, Katja M. | - |
dc.contributor.author | Griffin, Benjamin R. | - |
dc.contributor.author | Jovanovich, Anna | - |
dc.contributor.author | Reisz, Julie A. | - |
dc.contributor.author | Wither, Matthew J. | - |
dc.contributor.author | D'Alessandro, Angelo | - |
dc.contributor.author | Edelstein, Charles L. | - |
dc.contributor.author | Clendenen, Nathan | - |
dc.contributor.author | McKinsey, Timothy A. | - |
dc.contributor.author | Altmann, Christopher | - |
dc.contributor.author | Faubel, Sarah | - |
dc.date.accessioned | 2021-08-11T10:23:39Z | - |
dc.date.available | 2021-08-11T10:23:39Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 0085-2538 | - |
dc.identifier.issn | 1523-1755 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4713 | - |
dc.description.abstract | Acute kidney injury (AKI) is a systemic disease associated with widespread effects on distant organs, including the heart. Normal cardiac function is dependent on constant ATP generation, and the preferred method of energy production is via oxidative phosphorylation. Following direct ischemic cardiac injury, the cardiac metabolome is characterized by inadequate oxidative phosphorylation, increased oxidative stress, and increased alternate energy utilization. We assessed the impact of ischemic AKI on the metabolomics profile in the heart. Ischemic AKI was induced by 22 minutes of renal pedicle clamping, and 124 metabolites were measured in the heart at 4 hours, 24 hours, and 7 days post-procedure. Forty-one percent of measured metabolites were affected, with the most prominent changes observed 24 hours post-AKI. The post-AKI cardiac metabolome was characterized by amino acid depletion, increased oxidative stress, and evidence of alternative energy production, including a shift to anaerobic forms of energy production. These metabolomic effects were associated with significant cardiac ATP depletion and with echocardiographic evidence of diastolic dysfunction. In the kidney, metabolomics analysis revealed shifts suggestive of energy depletion and oxidative stress, which were reflected systemically in the plasma. This is the first study to examine the cardiac metabolome after AKI, and demonstrates that effects of ischemic AKI on the heart are akin to the effects of direct ischemic cardiac injury. | - |
dc.format.extent | 21 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Inc. | - |
dc.title | Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.kint.2018.10.020 | - |
dc.identifier.scopusid | 2-s2.0-85060572070 | - |
dc.identifier.wosid | 000459161300017 | - |
dc.identifier.bibliographicCitation | Kidney International, v.95, no.3, pp 590 - 610 | - |
dc.citation.title | Kidney International | - |
dc.citation.volume | 95 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 590 | - |
dc.citation.endPage | 610 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | ACUTE-RENAL-FAILURE | - |
dc.subject.keywordPlus | AMINO-ACIDS | - |
dc.subject.keywordPlus | URIC-ACID | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | REPERFUSION | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | CREATININE | - |
dc.subject.keywordPlus | GLUTAMATE | - |
dc.subject.keywordAuthor | acute kidney injury | - |
dc.subject.keywordAuthor | cardiorenal syndrome | - |
dc.subject.keywordAuthor | metabolomics | - |
dc.subject.keywordAuthor | organ crosstalk | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.