Bariatric Surgery Alters microRNA Content of Circulating Exosomes in Patients with Obesity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, Yun-Ui | - |
dc.contributor.author | Kim, Yongjin | - |
dc.contributor.author | Lee, Haekyung | - |
dc.contributor.author | Kim, Hyoungnae | - |
dc.contributor.author | Jeon, Jin Seok | - |
dc.contributor.author | Noh, Hyunjin | - |
dc.contributor.author | Han, Dong Cheol | - |
dc.contributor.author | Ryu, Seongho | - |
dc.contributor.author | Kwon, Soon Hyo | - |
dc.date.accessioned | 2021-08-11T10:23:50Z | - |
dc.date.available | 2021-08-11T10:23:50Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 1930-7381 | - |
dc.identifier.issn | 1930-739X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4767 | - |
dc.description.abstract | Objective Exosomal microRNAs (miRNAs) are potential biomarkers for obesity, in which they regulate biological processes. Bariatric surgery has health benefits for patients with obesity; however, the mechanisms of these benefits are not clear. This study attempted to identify the exosomal miRNA signature associated with obesity and how it changed after bariatric surgery. Methods Healthy volunteers (HVs) and nondiabetic patients with obesity were prospectively enrolled in the study. The study assessed the serum exosomal miRNA profiles of HVs and patients with obesity using RNA sequencing. To evaluate the effects of bariatric surgery, the study also analyzed exosomal miRNAs in patients 6 months after surgery. Results RNA sequencing revealed differential expression of 72 exosomal miRNAs in patients with obesity compared with HVs and differential expression of 41 miRNAs in post- versus presurgery blood. Among the differentially expressed miRNAs, the study identified nine surgery-responsive miRNAs that were highly expressed in patients before surgery compared with HVs. Biological pathway analysis of the nine miRNAs indicated that they are likely involved in WNT, neurotrophin, and insulin signaling; the insulin receptor signaling cascade; and focal adhesion. Conclusions Patients with obesity have a distinct exosomal miRNA expression profile compared with HVs. In addition, weight loss after surgery alters the exosomal miRNA profile of patients with obesity. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Wiley-Blackwell | - |
dc.title | Bariatric Surgery Alters microRNA Content of Circulating Exosomes in Patients with Obesity | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/oby.22379 | - |
dc.identifier.scopusid | 2-s2.0-85059689335 | - |
dc.identifier.wosid | 000456722000011 | - |
dc.identifier.bibliographicCitation | Obesity, v.27, no.2, pp 264 - 271 | - |
dc.citation.title | Obesity | - |
dc.citation.volume | 27 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 264 | - |
dc.citation.endPage | 271 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MIRNAS | - |
dc.subject.keywordPlus | MIR-378 | - |
dc.subject.keywordAuthor | Bariatric Surgery Alters microRNA Contentof Circulating Exosomes in Patients with Obesity | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.