The impact of primary tumor location in patients with metastatic colorectal cancer: a Korean Cancer Study Group CO12-O4 study
DC Field | Value | Language |
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dc.contributor.author | Byun, Jae Ho | - |
dc.contributor.author | Ahn, Joong Bae | - |
dc.contributor.author | Kim, Sun Young | - |
dc.contributor.author | Kang, Jung Hun | - |
dc.contributor.author | Zang, Dae Young | - |
dc.contributor.author | Kang, Seok Yun | - |
dc.contributor.author | Kang, Myoung Joo | - |
dc.contributor.author | Shim, Byoung Yong | - |
dc.contributor.author | Baek, Sun Kyung | - |
dc.contributor.author | Kim, Bong-Seog | - |
dc.contributor.author | Lee, Kyung Hee | - |
dc.contributor.author | Lee, Soon Il | - |
dc.contributor.author | Cho, Sang-Hee | - |
dc.contributor.author | Sohn, Byeong Seok | - |
dc.contributor.author | Kim, Samyong | - |
dc.contributor.author | Hwang, In Gyu | - |
dc.contributor.author | Nam, Eun Mi | - |
dc.contributor.author | Seo, Bong-Gun | - |
dc.contributor.author | Oh, Sang Cheul | - |
dc.contributor.author | Lee, Myung-Ah | - |
dc.contributor.author | Lee, Sang-Cheol | - |
dc.contributor.author | Hong, Ji Hyung | - |
dc.contributor.author | Park, Young Suk | - |
dc.date.accessioned | 2021-08-11T10:24:04Z | - |
dc.date.available | 2021-08-11T10:24:04Z | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.issn | 2005-6648 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/4833 | - |
dc.description.abstract | Background/Aims: Colorectal cancer is associated with different anatomical, biological, and clinical characteristics. We determined the impact of the primary tumor location in patients with metastatic colorectal cancer (mCRC). Methods: Demographic data and clinical information were collected from 1,115 patients from the Republic of Korea, who presented with mCRC between January 2009 and December 2011, using web-based electronic case report forms. Associations between the primary tumor location and the patient's clinical characteristics were assessed, and factors influencing overall survival were analyzed using Cox proportional hazards regression models. Results: Of the 1,115 patients recruited to the study, 244 (21.9%) had right colon cancer, 483 (43.3%) had left colon cancer, and 388 (34.8%) had rectal cancer. Liver and lung metastases occurred more frequently in patients with left colon and rectal cancer (p = 0.005 and p = 0.006, respectively), while peritoneal and ovarian metastases occurred more frequently in patients with right and left colon cancer (p < 0.001 and p = 0.031, respectively). The median overall survival of patients with tumors originating in the right colon was significantly shorter than that of patients whose tumors had originated in the left colon or rectum (13.7 months [95% confidence interval (CI), 12.0 to 15.5] vs. 18.0 months [95% CI, 16.3 to 19.71 or 19.9 months [95% CI, 18.5 to 21.3], respectively; p = 0.003). Tumor resection, the number of metastatic sites, and primary tumor location correlated with overall survival in the univariate and multivariate analyses. Conclusions: Primary tumor location influences the metastatic sites and prognosis of patients with mCRC. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한내과학회 | - |
dc.title | The impact of primary tumor location in patients with metastatic colorectal cancer: a Korean Cancer Study Group CO12-O4 study | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3904/kjim.2016.348 | - |
dc.identifier.scopusid | 2-s2.0-85059503252 | - |
dc.identifier.wosid | 000454539700017 | - |
dc.identifier.bibliographicCitation | The Korean Journal of Internal Medicine, v.34, no.1, pp 165 - 177 | - |
dc.citation.title | The Korean Journal of Internal Medicine | - |
dc.citation.volume | 34 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 165 | - |
dc.citation.endPage | 177 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002415432 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | MICROSATELLITE INSTABILITY | - |
dc.subject.keywordPlus | COLON | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | BEVACIZUMAB | - |
dc.subject.keywordPlus | CETUXIMAB | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | STATISTICS | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordAuthor | Colorectal neoplasms | - |
dc.subject.keywordAuthor | Primary tumor location | - |
dc.subject.keywordAuthor | Survival | - |
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