The rivaroxaban-adjusted normalized ratio: use of the prothrombin time to monitor the therapeutic effect of rivaroxaban
DC Field | Value | Language |
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dc.contributor.author | Kim, B. | - |
dc.contributor.author | Jang, S. | - |
dc.contributor.author | Lee, Y. J. | - |
dc.contributor.author | Park, N. | - |
dc.contributor.author | Cho, Y. U. | - |
dc.contributor.author | Park, C. J. | - |
dc.date.accessioned | 2021-08-11T11:23:35Z | - |
dc.date.available | 2021-08-11T11:23:35Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0967-4845 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5303 | - |
dc.description.abstract | Background: The prothrombin time may be used to monitor the plasma concentration of rivaroxaban. However, there is variability in the responsiveness of rivaroxaban to different thromboplastins. We aimed to develop a rivaroxaban-monitoring method using the prothrombin time to reduce the differences in the sensitivity among reagents. Methods: Rivaroxaban-spiked pooled normal plasma at a 0-1000 ng/ml concentration was used to generate a rivaroxaban-adjusted sensitivity index (SI) values, and was tested with three thromboplastins. The warfarin-adjusted international sensitivity index (ISI-warfarin), rivaroxaban-adjusted sensitivity index (SI-rivaroxaban), international normalized ratio (INR) calculated with ISI-warfarin, normalized ratio (NR) calculated with SI-rivaroxaban, and their coefficient of variances (CVs) were compared. The NR-rivaroxaban value was compared with the results of an anti-Xa assay. Results: The ISI-warfarin and SI-rivaroxaban using different thromboplastins were 1.02 and 1.88, respectively, with Thromborel S, 0.90 and 1.00 using Recombiplastin 2G, and 1.30 and 1.15 using Neoplastin CI-plus. Between-thromboplastin variability expressed as CV were 6.3%-25.1% when expressed as INR-warfarin and 1.7%-4.7% when expressed as NR-rivaroxaban. CVs for the NR-rivaroxaban with another laboratory were significantly lower than those for INR-warfarin. Anti-Xa assay v NR-rivaroxaban correlation coefficients were 0.97-0.99. Conclusion: Using a rivaroxaban-specific NR effectively minimises inter-thromboplastin variability. By utilizing a NR-rivaroxaban, standardized prothrombin time results could be rapidly obtained, especially useful in standardizing the therapeutic effect of rivaroxaban. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BioMed Central | - |
dc.title | The rivaroxaban-adjusted normalized ratio: use of the prothrombin time to monitor the therapeutic effect of rivaroxaban | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1080/09674845.2019.1605648 | - |
dc.identifier.scopusid | 2-s2.0-85067573607 | - |
dc.identifier.wosid | 000504232000004 | - |
dc.identifier.bibliographicCitation | British Journal of Biomedical Science, v.76, no.3, pp 122 - 128 | - |
dc.citation.title | British Journal of Biomedical Science | - |
dc.citation.volume | 76 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 122 | - |
dc.citation.endPage | 128 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.subject.keywordPlus | DIRECT ORAL ANTICOAGULANTS | - |
dc.subject.keywordPlus | LABORATORY MEASUREMENT | - |
dc.subject.keywordPlus | PHARMACODYNAMICS | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | ASSAYS | - |
dc.subject.keywordPlus | INR | - |
dc.subject.keywordAuthor | International normalized ratio (INR) | - |
dc.subject.keywordAuthor | international standardization index (ISI) | - |
dc.subject.keywordAuthor | prothrombin time | - |
dc.subject.keywordAuthor | rivaroxaban | - |
dc.subject.keywordAuthor | standardization | - |
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