Anti-Inflammatory Activity of Populus deltoides Leaf Extract via Modulating NF-kappa B and p38/JNK Pathways
DC Field | Value | Language |
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dc.contributor.author | Jeong, Ye Eun | - |
dc.contributor.author | Lee, Mi-Young | - |
dc.date.accessioned | 2021-08-11T11:23:56Z | - |
dc.date.available | 2021-08-11T11:23:56Z | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5443 | - |
dc.description.abstract | Populus deltoides, known as eastern cottonwood, has been commonly used as a medicinal plant. The aim of the present study was to investigate the mechanism underlying the anti-inflammatory activity of P. deltoides leaf extract (PLE). PLE effectively inhibited the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, but not that of cyclooxygenase-2 (COX-2) and prostaglandin E2. Proinflammatory tumor necrosis factor alpha (TNF-alpha) levels were also reduced by the extract. PLE inhibited the phosphorylation of nuclear factor-kappa B (NF-kappa B) and inhibitor of Kappa B alpha (I kappa B alpha), and blunted LPS-triggered enhanced nuclear translocation of NF-kappa B p65. In mitogen-activated protein kinase (MAPK) signaling, PLE effectively decreased the phosphorylation of p38 and c-Jun N-terminal protein kinase (JNK), but not of extracellular signal-regulated kinase 1/2 (ERK1/2). Taken together, these results suggest that anti-inflammatory activity of P. deltoides leaf extract might be driven by iNOS and NO inhibition mediated by modulation of the NF-kappa B and p38/JNK signaling pathways. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Anti-Inflammatory Activity of Populus deltoides Leaf Extract via Modulating NF-kappa B and p38/JNK Pathways | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/ijms19123746 | - |
dc.identifier.scopusid | 2-s2.0-85057158738 | - |
dc.identifier.wosid | 000455323500048 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.19, no.12 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 19 | - |
dc.citation.number | 12 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE-INDUCED INFLAMMATION | - |
dc.subject.keywordPlus | LPS-INDUCED INFLAMMATION | - |
dc.subject.keywordPlus | PHENOLIC GLYCOSIDES | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | MAPK | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | COX-2 | - |
dc.subject.keywordPlus | BARK | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | Populus deltoides leaf | - |
dc.subject.keywordAuthor | iNOS | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordAuthor | NF-kappa B | - |
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