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Enantioselective Organocatalytic Mannich Reaction and Fluorination Sequence of Pyrazolones to Isatin-derived Ketimines
- Authors
- Jung, Hye Im; Park, Jin Hwa; Kim, Dae Young
- Issue Date
- Dec-2018
- Publisher
- 대한화학회
- Keywords
- Oxindole-pyrazolone adducts; Bifunctional organocatalyst; Ketimines; Pyrazolones
- Citation
- Bulletin of the Korean Chemical Society, v.39, no.12, pp 1442 - 1448
- Pages
- 7
- Journal Title
- Bulletin of the Korean Chemical Society
- Volume
- 39
- Number
- 12
- Start Page
- 1442
- End Page
- 1448
- ISSN
- 0253-2964
1229-5949
- Abstract
- An efficient asymmetric synthesis of oxindole-pyrazolone adducts via organocatalytic Mannich reaction of 1-phenyl-1H-pyrazol-5(4H)-ones with ketimine derivatives derived from isatins, followed by sequential electrophilic fluorination, has been developed. This approach offers a facile way to prepare chiral 3-amino-3-(4-fluoropyrazol-4-yl)-substituted oxindole derivatives with a wide range of functional group tolerance.
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Related Researcher
- Kim, Dae Young
- College of Natural Sciences (Department of Chemistry)