Preparation of a Camptothecin-conjugated Molecular Carrier and its Cytotoxic Effect Toward Human Colorectal Carcinoma In Vitro
- Authors
- Jeong, Dongjun; Pal, Tarun; Kim, Hyungjoo; Kim, Tae Wan; Biswas, Goutam; Lee, Daeun; Singh, Tejinder; Murthy, Akula S. N.; Kim, Wanil; Kim, Kyong-Tai; Im, Jungkyun
- Issue Date
- Dec-2018
- Publisher
- 대한화학회
- Keywords
- Camptothecin; Colorectal cancer; Drug delivery; Molecular carrier
- Citation
- Bulletin of the Korean Chemical Society, v.39, no.12, pp 1385 - 1393
- Pages
- 9
- Journal Title
- Bulletin of the Korean Chemical Society
- Volume
- 39
- Number
- 12
- Start Page
- 1385
- End Page
- 1393
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5456
- DOI
- 10.1002/bkcs.11611
- ISSN
- 0253-2964
1229-5949
- Abstract
- Camptothecin (CPT) and its derivatives are the only chemical class that targets the enzymatic activity of DNA topoisomerase I, which is involved in DNA damage and subsequent cell apoptosis. Despite CPT's advantages, its use has been restricted due to extremely poor solubility, drug resistance by several efflux pumps, short half-life, and poor bioavailability. To overcome these limitations, we designed and synthesized a water-soluble CPT-conjugated molecular transporter that successfully and rapidly delivered CPT into cells. The conjugate had affinity toward mitochondria inside cells and it was distributed mainly to kidney, lung, and spleen. MTT assay confirmed that the CPP-conjugate decreased cell viability of colon cancer cell lines to a much greater extent than the parent drug. This novel approach has the potential of improving CPT efficacy for future in vivo applications, especially for colon cancer therapy.
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- Appears in
Collections - College of Engineering > Department of Chemical Engineering > 1. Journal Articles
- College of Medicine > Department of Pathology > 1. Journal Articles
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