Prospective Intraindividual Comparison of Magnetic Resonance Imaging With Gadoxetic Acid and Extracellular Contrast for Diagnosis of Hepatocellular Carcinomas Using the Liver Imaging Reporting and Data System
DC Field | Value | Language |
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dc.contributor.author | Min, Ji Hye | - |
dc.contributor.author | Kim, Jong Man | - |
dc.contributor.author | Kim, Young Kon | - |
dc.contributor.author | Kang, Tae Wook | - |
dc.contributor.author | Lee, Soon Jin | - |
dc.contributor.author | Choi, Gyu Seong | - |
dc.contributor.author | Choi, Seo-Youn | - |
dc.contributor.author | Ahn, Soohyun | - |
dc.date.accessioned | 2021-08-11T11:24:01Z | - |
dc.date.available | 2021-08-11T11:24:01Z | - |
dc.date.issued | 2018-12 | - |
dc.identifier.issn | 0270-9139 | - |
dc.identifier.issn | 1527-3350 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5467 | - |
dc.description.abstract | We intraindividually compared the efficacy of magnetic resonance imaging (MRI) with extracellular contrast agents (ECA-MRI) and MRI with hepatobiliary agents (HBA-MRI) for the diagnosis of hepatocellular carcinoma (HCC) using the Liver Imaging Reporting and Data System (LI-RADS). Between November 2016 and November 2017, we enrolled 91 patients with chronic liver disease who underwent both ECA-MRI and HBA-MRI within a 1-month interval for a first detected hepatic nodule on ultrasound. In total, 117 observations (95 HCCs, 19 benign lesions, and 3 other malignancies; median size, 18 mm) were identified with surgical resection. Two observers assessed two MRIs based on LI-RADS v2017, with consensus by a third observer. We then compared the diagnostic performance of LR-5 according to LI-RADS and modified LI-RADS. ECA-MRI had higher sensitivity (77.9% versus 66.3%) and accuracy (82.1% versus 72.6%) than HBA-MRI in the LR-5 category (P < 0.001). When applying either modified washout on the portal venous phase (PVP)/transitional phase (TP) of HBA-MRI or isointensity with a capsule during the PVP/delayed phase of ECA-MRI (illusional washout), 13 HCCs on HBA-MRI and 11 HCCs on ECA-MRI were correctly classified as HCC, while achieving 100% specificity. One cholangiocarcinoma was accurately classified only with HBA-MRI due to its targetoid appearance in the TP and hepatobiliary phase. Conclusion: ECA-MRI showed better sensitivity and accuracy than HBA-MRI for the diagnosis of HCC with LI-RADS. We achieved better diagnostic performance when applying a modified washout on PVP/TP HBA-MRI and an illusional washout on ECA-MRI than we did with conventional criteria. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley & Sons Inc. | - |
dc.title | Prospective Intraindividual Comparison of Magnetic Resonance Imaging With Gadoxetic Acid and Extracellular Contrast for Diagnosis of Hepatocellular Carcinomas Using the Liver Imaging Reporting and Data System | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/hep.30122 | - |
dc.identifier.scopusid | 2-s2.0-85056336215 | - |
dc.identifier.wosid | 000451622600059 | - |
dc.identifier.bibliographicCitation | Hepatology, v.68, no.6, pp 2254 - 2267 | - |
dc.citation.title | Hepatology | - |
dc.citation.volume | 68 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2254 | - |
dc.citation.endPage | 2267 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | GD-EOB-DTPA | - |
dc.subject.keywordPlus | HEPATOBILIARY PHASE | - |
dc.subject.keywordPlus | ENHANCED MRI | - |
dc.subject.keywordPlus | HYPOINTENSE NODULES | - |
dc.subject.keywordPlus | CLINICAL-EVALUATION | - |
dc.subject.keywordPlus | CIRRHOTIC LIVER | - |
dc.subject.keywordPlus | LI-RADS | - |
dc.subject.keywordPlus | CT | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordPlus | WASHOUT | - |
dc.subject.keywordAuthor | Gadoxetic Acid | - |
dc.subject.keywordAuthor | Extracellular | - |
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