Hypoxic Preconditioned Mesenchymal Stromal Cell Therapy in a Rat Model of Renal Ischemia-reperfusion Injury: Development of Optimal Protocol to Potentiate Therapeutic Efficacy
DC Field | Value | Language |
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dc.contributor.author | Jang, Myoung Jin | - |
dc.contributor.author | You, Dalsan | - |
dc.contributor.author | Park, Jin Young | - |
dc.contributor.author | Kim, Kyung | - |
dc.contributor.author | Aum, Joomin | - |
dc.contributor.author | Lee, Chunwoo | - |
dc.contributor.author | Song, Geehyun | - |
dc.contributor.author | Shin, Ha Chul | - |
dc.contributor.author | Suh, Nayoung | - |
dc.contributor.author | Kim, Yong Man | - |
dc.contributor.author | Kim, Choung-Soo | - |
dc.date.accessioned | 2021-08-11T11:24:11Z | - |
dc.date.available | 2021-08-11T11:24:11Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 2005-3606 | - |
dc.identifier.issn | 2005-5447 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5519 | - |
dc.description.abstract | Although previous and ongoing clinical studies have used stromal cells during renal ischemia-reperfusion injury (IRI), there is little consensus regarding the optimal protocol. We aimed to optimize the protocol for hypoxic preconditioned human bone marrow-derived mesenchymal stromal cell (HP-hBMSC) therapy in a rat model of renal IRI. We determined the optimal injection route (renal arterial, renal parenchymal, and tail venous injection), dose (low-dose: 1x10(6), moderate-dose: 2x10(6), and high-dose: 4x10(6)), and injection period (pre-, concurrent-, and post-IRI). During optimal injection route study, renal arterial injections significantly reduced the decreasing glomerular filtration rate (GFR), as compared to GFRs for the IRI control group, 2 and 4 days after IRI. Therapeutic effects and histological recoveries were the greatest in the group receiving renal arterial injections. During the dose finding study, high-dose injections significantly reduced the decreasing GFR, as compared to GFRs for the IRI control group, 3 days after IRI. Therapeutic effects and histological recoveries were the greatest in the high-dose injection group. While determining the optimal injection timing study, concurrent-IRI injection reduced elevated serum creatinine levels, as compared to those of the IRI control group, 1 day after IRI. Pre-IRI injection significantly reduced the decreasing GFR, as compared with GFRs for the IRI control group, 1 day after IRI. Therapeutic effects and histological recoveries were the greatest in the concurrent-IRI group. In conclusion, the concurrent-IRI administration of a high dose of HP-hBMSC via the renal artery leads to an optimal recovery of renal function after renal IRI. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korean Society for Stem Cell Research | - |
dc.title | Hypoxic Preconditioned Mesenchymal Stromal Cell Therapy in a Rat Model of Renal Ischemia-reperfusion Injury: Development of Optimal Protocol to Potentiate Therapeutic Efficacy | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.15283/ijsc18073 | - |
dc.identifier.wosid | 000454044400002 | - |
dc.identifier.bibliographicCitation | International Journal of Stem Cells, v.11, no.2, pp 157 - + | - |
dc.citation.title | International Journal of Stem Cells | - |
dc.citation.volume | 11 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 157 | - |
dc.citation.endPage | + | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | ACUTE KIDNEY INJURY | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | RECOVERY | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | PROTECT | - |
dc.subject.keywordPlus | HEART | - |
dc.subject.keywordAuthor | Ischemia-reperfusion injury | - |
dc.subject.keywordAuthor | Acute kidney injury | - |
dc.subject.keywordAuthor | Hypoxia preconditioning | - |
dc.subject.keywordAuthor | Cell therapy | - |
dc.subject.keywordAuthor | Renal function | - |
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