Kaempferia parviflora Extract as a Potential Anti-Acne Agent with Anti-Inflammatory, Sebostatic and Anti-Propionibacterium acnes Activity
DC Field | Value | Language |
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dc.contributor.author | Jin, Solee | - |
dc.contributor.author | Lee, Mi-Young | - |
dc.date.accessioned | 2021-08-11T11:43:29Z | - |
dc.date.available | 2021-08-11T11:43:29Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5543 | - |
dc.description.abstract | Kaempferia parviflora, referred to as black ginger, has traditionally been used as a health-promoting alternative medicine. In this study, we examined the anti-inflammatory, sebostatic, and anti-Propionibacterium acnes activities of K. parviflora extract. The extract significantly down-regulated the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), and pro-inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) level. Moreover, the phosphorylation of IkB alpha and nuclear factor-kappa B (NF-kappa B), and the enhanced nuclear translocation of NF-kappa B p65 in lipopolysaccharide-stimulated murine macrophage-like cell line (RAW 264.7) cells were markedly decreased by the extract. Notably, the main component of K. parviflora, 5,7-dimethoxyflavone, also modulated the expression of iNOS and NF-kappa B signal molecules in P. acnes-stimulated human keratinocyte (HaCaT) cells. Additionally, K. parviflora extract inhibited the lipogenesis of sebocytes, as evidenced by a reduced level of triglyceride and lipid accumulation in the sebocytes. The sebostatic effect was also confirmed by a reduced expression of peroxisome proliferation-activating receptors (PPAR-gamma) and oil-red O staining in sebocytes. Taken together, this study suggests for the first time that K. parviflora extract could be developed as a potential natural anti-acne agent with anti-inflammatory, sebostatic, and anti-P. acnes activity. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Kaempferia parviflora Extract as a Potential Anti-Acne Agent with Anti-Inflammatory, Sebostatic and Anti-Propionibacterium acnes Activity | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/ijms19113457 | - |
dc.identifier.scopusid | 2-s2.0-85056132790 | - |
dc.identifier.wosid | 000451528500173 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.19, no.11 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 19 | - |
dc.citation.number | 11 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | COX-2 EXPRESSION | - |
dc.subject.keywordPlus | SEBACEOUS GLAND | - |
dc.subject.keywordPlus | LIPOGENESIS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | INOS | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordAuthor | Kaempferia parviflora | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordAuthor | sebostatic effect | - |
dc.subject.keywordAuthor | anti-P. acnes effect | - |
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