PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models
DC Field | Value | Language |
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dc.contributor.author | Yong, Ji In | - |
dc.contributor.author | Kim, Dae Won | - |
dc.contributor.author | Shin, Min Jea | - |
dc.contributor.author | Jo, Hyo Sang | - |
dc.contributor.author | Park, Jung Hwan | - |
dc.contributor.author | Cho, Su Bin | - |
dc.contributor.author | Lee, Chi Hem | - |
dc.contributor.author | Yeo, Hyeon Ji | - |
dc.contributor.author | Yeo, Eun Ji | - |
dc.contributor.author | Choi, Yeon Joo | - |
dc.contributor.author | Kim, Ji An | - |
dc.contributor.author | Hwang, Jung Soon | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.contributor.author | Kim, Hyun Ah | - |
dc.contributor.author | Cho, Yong-Jun | - |
dc.contributor.author | Lee, Keun Wook | - |
dc.contributor.author | Han, Kyu Hyung | - |
dc.contributor.author | Park, Jinseu | - |
dc.contributor.author | Eum, Won Sik | - |
dc.contributor.author | Choi, Soo Young | - |
dc.date.accessioned | 2021-08-11T11:43:30Z | - |
dc.date.available | 2021-08-11T11:43:30Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 0171-2985 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5548 | - |
dc.description.abstract | Phosphoprotein enriched in astrocytes 15 (PEA15) plays a multi-functional role in neuronal cell survival, however the effects of PEA15 against inflammation have not been investigated yet. To examine the effects of PEP-1-PEA15 protein against lipopolysaccharide (LPS)-induced inflammatory responses in Raw 264.7 cells and in a 12-O-tetradecanoylphobol 13-acetate (TPA)-induced mouse model, we constructed and purified PEP-1-PEA15 protein, which can transduce into cells or tissues. PEP-1-PEA15 inhibited LPS-induced damage in cells including that caused by reactive oxygen species (ROS) production and DNA fragmentation. PEP-1-PEA15 also significantly suppressed activation of mitogen activated protein kinases (MAPKs), pro-inflammatory mediator proteins and various cytokines. In a TPA-induced mouse ear edema model, PEP-1-PEA15 significantly reduced ear weight and thickness as well as MAPK activation as well as the expression levels of COX-2, iNOS, IL-6, IL-1 beta, and TNF-alpha. These results demonstrated that PEP-1-PEA15 showed anti-inflammatory effect in cells and animal model suggesting that this fusion protein protects cells or skin tissues from inflammatory response. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1016/j.imbio.2018.07.019 | - |
dc.identifier.scopusid | 2-s2.0-85050212529 | - |
dc.identifier.wosid | 000446807400014 | - |
dc.identifier.bibliographicCitation | Immunobiology, v.223, no.11, pp 709 - 717 | - |
dc.citation.title | Immunobiology | - |
dc.citation.volume | 223 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 709 | - |
dc.citation.endPage | 717 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | ASTROCYTIC PHOSPHOPROTEIN PEA-15 | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | SKIN INFLAMMATION | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | RAW 264.7 | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PED/PEA-15 | - |
dc.subject.keywordAuthor | PEP-1-PEA15 | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | MAPK | - |
dc.subject.keywordAuthor | Cytokines | - |
dc.subject.keywordAuthor | Protein therapy | - |
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