Long-term Outcome of Resective Epilepsy Surgery in Patients With Lennox-Gastaut Syndrome
DC Field | Value | Language |
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dc.contributor.author | Kang, Joon Won | - |
dc.contributor.author | Eom, Soyong | - |
dc.contributor.author | Hong, William | - |
dc.contributor.author | Kwon, Hye Eun | - |
dc.contributor.author | Park, Soyoung | - |
dc.contributor.author | Ko, Ara | - |
dc.contributor.author | Kang, Hoon-Chul | - |
dc.contributor.author | Lee, Joon Soo | - |
dc.contributor.author | Lee, Young-Mock | - |
dc.contributor.author | Kim, Dong Seok | - |
dc.contributor.author | Kim, Heung Dong | - |
dc.date.accessioned | 2021-08-11T11:43:40Z | - |
dc.date.available | 2021-08-11T11:43:40Z | - |
dc.date.issued | 2018-10 | - |
dc.identifier.issn | 0031-4005 | - |
dc.identifier.issn | 1098-4275 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5600 | - |
dc.description.abstract | OBJECTIVE: We aimed to evaluate the long-term outcome of resective epilepsy surgery in patients with Lennox-Gastaut syndrome (LGS). METHODS: We reviewed the case reports of 90 patients with LGS who had undergone resective surgery between 2003 and 2014 at the Severance Children's Hospital and managed them for a minimum period of 2 years. RESULTS: At the time of surgery, the patients were between 3.0 and 23.5 years old (mean SD: 9.3 +/- 4.4). The time from seizure onset to surgery ranged from 0.7 to 20.1 years (7.2 +/- 4.3). On postoperative follow-up for an average period of 6.1 +/- 2.2 years (range: 2.1-11.4 years), 45 patients (50.0%) had no seizures, and 15 (16.7%) reported infrequent seizures. Seizure-free outcomes were achieved in 15 of the 21 (71.4%) hemispherectomies, 23 of the 51 (45.1%) multilobar resections, and 7 of the 18 (38.9%) single lobar resections. On high-resolution MRIs, 20 patients (22.2%) had negative findings, 8 of whom (40.0%) became seizure-free after resective surgery. Malformation of cortical development was the most common pathologic finding and was noted in 57 patients (63.3%). Seizure-free patients achieved better adaptive behavior and social competence than did patients with persistent seizures at the second (2-3 years after surgery) and third (4-6 years after surgery) follow-ups, as indicated by social quotients (P < .05). CONCLUSIONS: Resective surgery is a viable option in some patients to treat seizures that are associated with LGS, with a high probability of seizure control and better adaptive function. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | American Academy of Pediatrics | - |
dc.title | Long-term Outcome of Resective Epilepsy Surgery in Patients With Lennox-Gastaut Syndrome | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1542/peds.2018-0449 | - |
dc.identifier.scopusid | 2-s2.0-85054064388 | - |
dc.identifier.wosid | 000449034300019 | - |
dc.identifier.bibliographicCitation | Pediatrics, v.142, no.4 | - |
dc.citation.title | Pediatrics | - |
dc.citation.volume | 142 | - |
dc.citation.number | 4 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | DRUG-RESISTANT EPILEPSY | - |
dc.subject.keywordPlus | HOC TASK-FORCE | - |
dc.subject.keywordPlus | CORTICAL DYSPLASIAS | - |
dc.subject.keywordPlus | REFRACTORY EPILEPSY | - |
dc.subject.keywordPlus | TREATMENT OPTIONS | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | DEFINITION | - |
dc.subject.keywordPlus | COMMISSION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordAuthor | 소아과학 | - |
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