Lung Function Trajectory Types in Never-Smoking Adults With Asthma: Clinical Features and Inflammatory Patterns
DC Field | Value | Language |
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dc.contributor.author | Kim, Joo-Hee | - |
dc.contributor.author | Chang, Hun Soo | - |
dc.contributor.author | Shin, Seung Woo | - |
dc.contributor.author | Baek, Dong Gyu | - |
dc.contributor.author | Son, Ji-Hye | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.contributor.author | Park, Jong-Sook | - |
dc.date.accessioned | 2021-08-11T11:43:51Z | - |
dc.date.available | 2021-08-11T11:43:51Z | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.issn | 2092-7363 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5658 | - |
dc.description.abstract | Purpose: Asthma is a heterogeneous disease that responds to medications to varying degrees. Cluster analyses have identified several phenotypes and variables related to fixed airway obstruction; however, few longitudinal studies of lung function have been performed on adult asthmatics. We investigated clinical, demographic, and inflammatory factors related to persistent airflow limitation based on lung function trajectories over 1 year. Methods: Serial post-bronchodilator forced expiratory volume (FEV) 1% values were obtained from 1,679 asthmatics who were followed up every 3 months for 1 year. First, a hierarchical cluster analysis was performed using Ward's method to generate a dendrogram for the optimum number of clusters using the complete post-FEV1 sets from 448 subjects. Then, a trajectory cluster analysis of serial post-FEV1 sets was performed using the k-means clustering for the longitudinal data trajectory method. Next, trajectory clustering for the serial post-FEV1 sets of a total of 1,679 asthmatics was performed after imputation of missing post-FEV1 values using regression methods. Results: Trajectories 1 and 2 were associated with normal lung function during the study period, and trajectory 3 was associated with a reversal to normal of the moderately decreased baseline FEV1 within 3 months. Trajectories 4 and 5 were associated with severe asthma with a marked reduction in baseline FEV1. However, the FEV1 associated with trajectory 4 was increased at 3 months, whereas the FEV1 associated with trajectory 5 was persistently disturbed over 1 year. Compared with trajectory 4, trajectory 5 was associated with older asthmatics with less atopy, a lower immunoglobulin E (IgE) level, sputum neutrophilia and higher dosages of oral steroids. In contrast, trajectory 4 was associated with higher sputum and blood eosinophil counts and more frequent exacerbations. Conclusions: Trajectory clustering analysis of FEV1 identified 5 distinct types, representing well-preserved to severely decreased FEV1. Persistent airflow obstruction may be related to non-atopy, a low IgE level, and older age accompanied by neutrophilic inflammation and low baseline FEV1 levels. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한천식알레르기학회 | - |
dc.title | Lung Function Trajectory Types in Never-Smoking Adults With Asthma: Clinical Features and Inflammatory Patterns | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4168/aair.2018.10.6.614 | - |
dc.identifier.scopusid | 2-s2.0-85054963000 | - |
dc.identifier.wosid | 000454569400017 | - |
dc.identifier.bibliographicCitation | Allergy, Asthma & Immunology Research, v.10, no.5-6, pp 614 - 627 | - |
dc.citation.title | Allergy, Asthma & Immunology Research | - |
dc.citation.volume | 10 | - |
dc.citation.number | 5-6 | - |
dc.citation.startPage | 614 | - |
dc.citation.endPage | 627 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002428096 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | AIR-FLOW LIMITATION | - |
dc.subject.keywordPlus | NEUTROPHILIC INFLAMMATION | - |
dc.subject.keywordPlus | FUNCTION DECLINE | - |
dc.subject.keywordPlus | CLUSTER-ANALYSIS | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | PHENOTYPES | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | EXACERBATIONS | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordAuthor | Adult | - |
dc.subject.keywordAuthor | asthma | - |
dc.subject.keywordAuthor | disease progression | - |
dc.subject.keywordAuthor | forced expiratory volume | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | phenotype | - |
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