Effect of Dapagliflozin on Alanine Aminotransferase Improvement in Type 2 Diabetes Mellitus with Non-alcoholic Fatty Liver Disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Dug-Hyun | - |
dc.contributor.author | Jung, Chan-Hee | - |
dc.contributor.author | Mok, Ji-Oh | - |
dc.contributor.author | Kim, Chul-Hee | - |
dc.contributor.author | Kang, Sung-Koo | - |
dc.contributor.author | Kim, Bo-Yeon | - |
dc.date.accessioned | 2021-08-11T11:43:58Z | - |
dc.date.available | 2021-08-11T11:43:58Z | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 2093-596X | - |
dc.identifier.issn | 2093-5978 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5690 | - |
dc.description.abstract | Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are expected to improve the liver function of patients with nonalcoholic fatty liver disease (NAFLD) combined type 2 diabetes mellitus (T2DM) by its characteristic mechanism. This study was designed to investigate the effect of dapagliflozin, one of the SGLT2i, on the liver function of T2DM with NAFLD when combined with metformin. Methods: Among patients who received dual oral hypoglycemic agents within the 3 months of diagnosing NAFLD, patients who had abnormal alanine aminotransferase (ALT) level (>40 IU/L) were included. Patients were divided into two groups: metformin+dapagliflozin group and metformin+dipeptidyl peptidase-4 inhibitors (DPP4i) group. Demographic data, biochemical data and the clinical and treatment histories of all patients were reviewed. Results: A total of 102 patients were included (dapagliflozin group, n=50; DPP4i group, n=52). Dapagliflozin group showed more weight loss and more ALT decline than DPP4i group (-2.9 kg vs. -0.4 kg. P = 0.005; -21.1 U/L vs. -9.5 U/L. P = 0.008, respectively) and the proportion of patients with ALT normalization after treatment was also significantly higher in the dapagliflozin group (80.0% vs. 61.5%, P=0.041). The effect of dapagliflozin with metformin on ALT normalization remained significant after adjustment for confounding variables including body weight loss (odds ratio, 3.489; P = 0.046). Conclusion: ALT improvement was statistically significant in the dapagliflozin than the DPP4i when combined with metformin and the result was consistent after adjustment for confounding variables including body weight loss. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한내분비학회 | - |
dc.title | Effect of Dapagliflozin on Alanine Aminotransferase Improvement in Type 2 Diabetes Mellitus with Non-alcoholic Fatty Liver Disease | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3803/EnM.2018.33.3.387 | - |
dc.identifier.scopusid | 2-s2.0-85054746424 | - |
dc.identifier.wosid | 000445207800010 | - |
dc.identifier.bibliographicCitation | Endocrinology and Metabolism, v.33, no.3, pp 387 - 394 | - |
dc.citation.title | Endocrinology and Metabolism | - |
dc.citation.volume | 33 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 387 | - |
dc.citation.endPage | 394 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002384937 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | esci | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | INADEQUATE GLYCEMIC CONTROL | - |
dc.subject.keywordPlus | COTRANSPORTER 2 INHIBITORS | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | CONTROLLED-TRIAL | - |
dc.subject.keywordPlus | METFORMIN | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | SULFONYLUREA | - |
dc.subject.keywordAuthor | Sodium-glucose cotransporter-2 inhibitor | - |
dc.subject.keywordAuthor | Diabetes mellitus, type 2 | - |
dc.subject.keywordAuthor | Non-alcoholic fatty liver disease | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.