In vitro assessments of bone microcomputed tomography in an aged male rat model supplemented with Panax ginseng
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hak-Jae | - |
dc.contributor.author | Park, Kyeong-Hun | - |
dc.contributor.author | Kim, Dong-Hwi | - |
dc.contributor.author | Chae, Han-Jung | - |
dc.contributor.author | Sung, Gi-Ho | - |
dc.contributor.author | Kim, Young-Ock | - |
dc.date.accessioned | 2021-08-11T11:43:59Z | - |
dc.date.available | 2021-08-11T11:43:59Z | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 1319-562X | - |
dc.identifier.issn | 2213-7106 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5696 | - |
dc.description.abstract | Recent research has confirmed that Panax ginseng (P. ginseng) has effect on cultured osteoblast of the mouse. In this study we aim to validate the usefulness of tibia quantification by correlating micro-computed tomographic (microCT) images with histology analysis in the aged male rats. A total of thirty - old male WISTAR rats were used and divided into ten 8 weeks rats and ten 112 weeks aged rats with vehicle and ten 112 weeks aged rats with P. ginseng (300 mg/kg/day). Daily oral administration of P. ginseng lasted for 8 weeks. Bone histomorphometric parameters and the trabecular bone microarchitectural properties of tibia were determined by microCT scan. MicroCT analysis showed significantly lower bone mineral density (BMD) and trabecular bone number in the aged group. Ginseng prevented total BMD decrease in the tibia induced by natural aging, which was accompanied by a significant decrease in skeletal remodeling. Furthermore, the aged group with ginseng was found to have a significantly higher osteoblast. In the blood biochemistry results, serum phosphorus, calcium, osteocalcin, T3, and T4 remained unchanged. The present study indicated that P. ginseng might be a potential alternative medicine for the prevention and treatment of natural aging-induced osteoporosis in human. (C) 2018 The Authors. Production and hosting by Elsevier B.V. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | King Saud University | - |
dc.title | In vitro assessments of bone microcomputed tomography in an aged male rat model supplemented with Panax ginseng | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.sjbs.2018.04.006 | - |
dc.identifier.scopusid | 2-s2.0-85046127907 | - |
dc.identifier.wosid | 000443059800019 | - |
dc.identifier.bibliographicCitation | Saudi Journal of Biological Sciences, v.25, no.6, pp 1135 - 1139 | - |
dc.citation.title | Saudi Journal of Biological Sciences | - |
dc.citation.volume | 25 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1135 | - |
dc.citation.endPage | 1139 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.subject.keywordPlus | TRABECULAR BONE | - |
dc.subject.keywordPlus | MORPHOMETRIC-ANALYSIS | - |
dc.subject.keywordPlus | COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | OSTEOPOROSIS | - |
dc.subject.keywordPlus | MAINTENANCE | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordAuthor | Microcomputed tomography | - |
dc.subject.keywordAuthor | Panax ginseng | - |
dc.subject.keywordAuthor | Osteoporosis | - |
dc.subject.keywordAuthor | Bone mineral density | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.