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Factors Associated with Health-Related Quality of Life in Korean Patients with Chronic Hepatitis C Infection Using the SF-36 and EQ-5D

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dc.contributor.authorJang, Eun Sun-
dc.contributor.authorKim, Young Seok-
dc.contributor.authorKim, Kyung-Ah-
dc.contributor.authorLee, Youn Jae-
dc.contributor.authorChung, Woo Jin-
dc.contributor.authorKim, In Hee-
dc.contributor.authorLee, Byung Seok-
dc.contributor.authorJeong, Sook-Hyang-
dc.date.accessioned2021-08-11T12:23:29Z-
dc.date.available2021-08-11T12:23:29Z-
dc.date.issued2018-07-
dc.identifier.issn1976-2283-
dc.identifier.issn2005-1212-
dc.identifier.urihttps://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5831-
dc.description.abstractBackground/Aims: This study aimed to describe the health-related quality of life (HRQoL) outcomes for Korean chronic hepatitis C patients and to investigate the impact of patient and virus-related factors on HRQoL. Methods: HRQoL was assessed in 235 hepatitis C virus (HCV)-infected patients from seven nationwide tertiary hospital, including those with liver cirrhosis and hepatocellular carcinoma (HCC), using the Shor-Form 36 (SF-36) version 2 and the European quality of life questionnaire-5 dimensions (EQ-5D-3L). Results: The SF36 physical (48.8 +/- 8.3) and mental (46.2 +/- 11.7) component summary scores of the HCV-infected patients were below normal limits. Of the eight domains, general health, vitality, and mental health tended to show low scores. Patients with decompensated cirrhosis had the lowest HRQoL, while HCC and chronic hepatitis patients had similar HRQoL results. The EQ-5D index was low (0.848 +/- 0.145) in the HCV infected patients. Multivariable analysis showed age 65 years, high monthly family income (>$2,641), low comorbidity score, and sustained virologjc response (SVR) were independently associated with favorable HRQoL. Conclusions: HRQoL in Korean patients with chronic HCV infection was low and was affected by cirrhosis severity, SVR, and comorbidity as well as income, which had the strongest effect. Therefore, HRQoL may be improved by antiviral therapy with reasonable costs to prevent cirrhosis progression.-
dc.format.extent9-
dc.language영어-
dc.language.isoENG-
dc.publisher거트앤리버 발행위원회-
dc.titleFactors Associated with Health-Related Quality of Life in Korean Patients with Chronic Hepatitis C Infection Using the SF-36 and EQ-5D-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.5009/gnl17322-
dc.identifier.scopusid2-s2.0-85049979129-
dc.identifier.wosid000436520300012-
dc.identifier.bibliographicCitationGut and Liver, v.12, no.4, pp 440 - 448-
dc.citation.titleGut and Liver-
dc.citation.volume12-
dc.citation.number4-
dc.citation.startPage440-
dc.citation.endPage448-
dc.type.docTypeArticle-
dc.identifier.kciidART002367597-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.subject.keywordPlusCHRONIC LIVER-DISEASE-
dc.subject.keywordPlusPEGYLATED INTERFERON-
dc.subject.keywordPlusPOPULATION-
dc.subject.keywordPlusRIBAVIRIN-
dc.subject.keywordPlusALGORITHM-
dc.subject.keywordPlusCIRRHOSIS-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordPlusVERSION-
dc.subject.keywordPlusPEOPLE-
dc.subject.keywordPlusBURDEN-
dc.subject.keywordAuthorQuality of life-
dc.subject.keywordAuthorHepatitis C-
dc.subject.keywordAuthorRepublic of Korea-
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