Factors Mediating Outcome After Stroke: Gender, Thrombolysis, and Their Interaction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seung-Jae | - |
dc.contributor.author | Heo, Sung Hyuk | - |
dc.contributor.author | Ambrosius, Walter T. | - |
dc.contributor.author | Bushnell, Cheryl D. | - |
dc.date.accessioned | 2021-08-11T12:23:45Z | - |
dc.date.available | 2021-08-11T12:23:45Z | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 1868-4483 | - |
dc.identifier.issn | 1868-601X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5925 | - |
dc.description.abstract | Several studies, but not all, have shown that women benefit more from intravenous thrombolysis than men; few have accounted for pre-stroke mobility. Our aim was to determine whether there was an interaction between gender and thrombolysis treatment in 3-month modified Rankin Scale (mRS) score, after adjusting for pre-stroke mobility. We retrospectively reviewed medical records of 1390 consecutive ischemic stroke patients admitted between October 2012 and July 2015. The 3-month mRS was obtained from clinic visits. Thrombolysis-by-gender interaction was evaluated in univariate and multivariate analyses using ordinal logistic ("shift") regression with the full mRS range from 0 to 6 as the dependent variable. We included 926 (456 women and 470 men) patients with follow-up. Women were older (mean age 68.1 vs 65.8 years, P = 0.013), less likely to be treated with thrombolysis (15.6 vs 24.0%, P = 0.002), less often discharged to home (49.1 vs 59.6%, P = 0.001), and more likely to use ambulation aids pre-stroke (13.6 vs 8.5%, P = 0.014).Women had worse outcomes than men in those not treated with thrombolysis (mRS 3: 55.1 vs 40.1%, P < 0.001). In those who received thrombolysis, there were no gender differences (47.9 vs 50.4%, P = 0.736). In multivariable modeling, there was a significant gender-treatment interaction (P < 0.001), after adjustment for gender, pre-stroke ambulation aid use, age, age-by-gender interaction, initial stroke severity, diabetes, heart failure, and prior stroke. Our results show that women benefit from thrombolysis more than men, and the thrombolysis-by-gender interaction persists after adjustment for pre-stroke mobility impairment. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer Pub. Co., | - |
dc.title | Factors Mediating Outcome After Stroke: Gender, Thrombolysis, and Their Interaction | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s12975-017-0579-6 | - |
dc.identifier.scopusid | 2-s2.0-85032035746 | - |
dc.identifier.wosid | 000433990300009 | - |
dc.identifier.bibliographicCitation | Translational Stroke Research, v.9, no.3, pp 267 - 273 | - |
dc.citation.title | Translational Stroke Research | - |
dc.citation.volume | 9 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 267 | - |
dc.citation.endPage | 273 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | TISSUE-PLASMINOGEN ACTIVATOR | - |
dc.subject.keywordPlus | QUALITY-OF-LIFE | - |
dc.subject.keywordPlus | SEX-DIFFERENCES | - |
dc.subject.keywordPlus | SAFE IMPLEMENTATION | - |
dc.subject.keywordPlus | CARE | - |
dc.subject.keywordPlus | ALTEPLASE | - |
dc.subject.keywordPlus | REGISTRY | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | RECOVERY | - |
dc.subject.keywordAuthor | Gender differences | - |
dc.subject.keywordAuthor | Intravenous thrombolysis | - |
dc.subject.keywordAuthor | Stroke outcomes | - |
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