Microscopic hematuria is a risk factor of incident chronic kidney disease in the Korean general population: a community-based prospective cohort study
DC Field | Value | Language |
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dc.contributor.author | Kim, H. | - |
dc.contributor.author | Lee, M. | - |
dc.contributor.author | Cha, M. -U. | - |
dc.contributor.author | Nam, K. H. | - |
dc.contributor.author | An, S. Y. | - |
dc.contributor.author | Park, S. | - |
dc.contributor.author | Jhee, J. H. | - |
dc.contributor.author | Yun, H. -R. | - |
dc.contributor.author | Kee, Y. K. | - |
dc.contributor.author | Park, J. T. | - |
dc.contributor.author | Yoo, T. -H. | - |
dc.contributor.author | Kang, S. -W. | - |
dc.contributor.author | Han, S. H. | - |
dc.date.accessioned | 2021-08-11T12:23:45Z | - |
dc.date.available | 2021-08-11T12:23:45Z | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 1460-2725 | - |
dc.identifier.issn | 1460-2393 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/5928 | - |
dc.description.abstract | Background: Although asymptomatic microscopic hematuria (MH) is a common finding in clinical practice, its long-term outcome remains unknown. Aim: This study evaluated the clinical implication of MH in the general population using a large-scale long-term longitudinal cohort database. Methods: This study included 8719 participants from the Korean Genome and Epidemiology Study between 2001 and 2014. MH was defined as >= 5 red blood cells per high-power field in random urinalysis without evidence of pyuria. The primary study outcome measure was incident chronic kidney disease (CKD), defined as estimated glomerular filtration rate <60 ml min(-1) .1.73.m(-2). Results: During a median follow-up of 11.7 years, CKD occurred in 677 (7.8%) subjects. In Cox regression after adjustment for multiple confounders, subjects with MH had a significantly higher risk of incident CKD than those without [hazard ratio (HR) 1.45, 95% confidence interval (CI) 1.12-1.87; P = 0.005]. Isolated MH without proteinuria was also a risk factor of incident CKD (HR 1.37, 95% CI 1.04-1.79; P = 0.023) and the risk was further increased in MH with concomitant proteinuria (HR 5.41, 95% CI 2.54-11.49; P<0.001). In propensity score matching analysis after excluding subjects with proteinuria, multi-variable stratified Cox regression analysis revealed that subjects with isolated MH had a significantly higher risk of incident CKD than those without (HR 1.83, 95% CI 1.14-2.94; P = 0.012). Conclusion: The presence of MH is associated with an increased risk of incident CKD in the general population. Therefore, attentive follow-up is warranted in persons with MH for early detection of CKD. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Oxford University Press | - |
dc.title | Microscopic hematuria is a risk factor of incident chronic kidney disease in the Korean general population: a community-based prospective cohort study | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1093/qjmed/hcy054 | - |
dc.identifier.scopusid | 2-s2.0-85048569841 | - |
dc.identifier.wosid | 000435501200007 | - |
dc.identifier.bibliographicCitation | QJM - Monthly Journal of the Association of Physicians, v.111, no.6, pp 389 - 397 | - |
dc.citation.title | QJM - Monthly Journal of the Association of Physicians | - |
dc.citation.volume | 111 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 389 | - |
dc.citation.endPage | 397 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | IGA NEPHROPATHY | - |
dc.subject.keywordPlus | RENAL SURVIVAL | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | COST | - |
dc.subject.keywordAuthor | Microscopic hematuria | - |
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